Search for dissertations about: "drug susceptibility"

Showing result 1 - 5 of 118 swedish dissertations containing the words drug susceptibility.

2. 1. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy

   Author : Muhammad Junaid; Jarl ES Wikberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

   Abstract : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. READ MORE

4. 2. Tuberculosis : diagnosis and drug susceptibility testing where resources are scarce

   Author : Kristian Ängeby; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Tuberculosis; diagnosis; microscopy; drug susceptibility testing; low-income countries;

   Abstract : Background: Tuberculosis remains a major global public health problem. Not surprisingly, most cases of this disease occur in poor countries and an increasing number of patients harbor drug - resistant bacteria. The cornerstone of bacteriological diagnosis of tuberculosis is direct sputum smear microscopy. READ MORE

5. 3. Water-swelling tablets based on hydrophobically modified poly(acrylic acid) - Effects of amphiphiles on swelling and drug release

   Author : Patrik Knöös; Fysikalisk kemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drug deliver; Controlled release; Hydrophobically modified polymers; Surfactant-polymer interactions; Poorly soluble drug;

   Abstract : An important issue within the pharmaceutical world today is the increasing number of poorly soluble drugs. These often show a low bioavailability and a susceptibility to varying conditions in the intestine. READ MORE

6. 4. Reverse Transcriptase Activity Assays for Retrovirus Quantitation and Characterization

   Author : Anders Malmsten; Ulf Gyllensten; Clas Källander; Lynn Morris; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; retrovirus; reverse transcriptase; enzyme activity assay; MuLV; HIV; RT purification; viral load; drug susceptibility; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Abstract : Reverse transcriptase (RT) is a crucial enzyme for retrovirus replication, and its presence in the virion is indispensable for infectivity. This thesis illustrates the use of RT activity assays as tools for quantitation and characterization of different retroviruses, particularly HIV. READ MORE

7. 5. Drug resistance in mycobacterium tuberculosis

   Author : Getahun Abate; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

   Abstract : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. READ MORE