Search for dissertations about: "drug synergism"

Showing result 1 - 5 of 8 swedish dissertations containing the words drug synergism.

2. 1. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

   Author : Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

   Abstract : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. READ MORE

4. 2. Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria

   Author : Seema Gupta; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Artemisinin (ART) class of compounds are of special interest due to their rapid onset of action and high activity against multidrug resistant malaria. The major drawback in monotherapy with ART and its derivatives is the high rate of recrudescent infection. READ MORE

5. 3. Pharmacodynamic interactions of quinolines with other antimalarial compounds in vitro

   Author : Shelton Tendai Mariga; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Malaria; synergy; combination therapy; Plasmodium falciparum; amodiaquine; lumefantrine; resistance; pharmacodynamics;

   Abstract : Chemotherapy remains the most reliable means for the control of Plasmodium falciparum malaria. Unfortunately the parasite has been able to develop resistance to the majority of the antimalarials currently employed. READ MORE

6. 4. Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs

   Author : Chunli Chen; Ulrika Simonsson; Mats Karlsson; Sebastian Wicha; Bernd Meibohm; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tuberculosis; pharmacokinetics; pharmacodynamics; pharmacometrics; the Multistate Tuberculosis Pharmacometric model; the General Pharmacodynamic Interaction model; optimized design; rifampicin; isoniazid; ethambutol; pyrazinamide; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : Tuberculosis is an ancient infectious disease and a leading cause of death globally. Preclinical research is important for defining drugs and regimens which should be carried forward to human studies. READ MORE

7. 5. Sinomenine as a novel analgesic : mechanisms and applications

   Author : Tiansheng Shi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Chronic pain of various origins is a major health care issue affecting a large patient population, also bring significant social and economic cost on the society. Work presented in this thesis concerns novel methods of treatments for chronic pain using experimental models. READ MORE