Search for dissertations about: "drug toxicity"

Showing result 1 - 5 of 206 swedish dissertations containing the words drug toxicity.

  2. 1. Intracellular unbound drug concentrations : Methodology and application for understanding cellular drug exposure

    Author : André Mateus; Per Artursson; Pär Matsson; José A. G. Morais; Jeff Krise; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular unbound drug concentrations; free drug; drug binding; drug transport; drug accumulation; cellular drug response; drug target engagement; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Most known drug targets and metabolizing enzymes are located inside cells. Interactions with these proteins are determined by intracellular unbound drug concentrations. Assessing intracellular drug exposure is technically challenging, but essential for predicting pharmacokinetic, pharmacological, and toxicological profiles of new drugs. READ MORE

  4. 2. Towards new computational tools for predicting toxicity

    Author : Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

    Abstract : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. READ MORE

  5. 3. Translational Tumor Drug Delivery : Doxorubicin formulation performance, intracellular uptake and molecular diffusion

    Author : Oliver Degerstedt; Hans Lennernäs; Erik Sjögren; Per Hansson; Jessica Rosenholm; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; doxorubicin; drug diffusion; cellular uptake; drug delivery; PBPK modelling; hepatocellular carcinoma; emulsion; IC50; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Globally, hepatocellular carcinoma (HCC) is the most common form of liver cancer and a leading cause of cancer death. One important risk factor is liver cirrhosis and the disease progression is characterized by deposition of extracellular matrix proteins that form a fibrous network, which increases liver stiffness and may limit the effectiveness of different treatment strategies. READ MORE

  6. 4. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

    Author : Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

    Abstract : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. READ MORE

  7. 5. Proteomics informed investigation of human hepatocytes and liver tissue

    Author : Niklas Handin; Per Artursson; Peter Nygren; Tobias Sjöblom; Mårten Fryknäs; Pieter Annaert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; liver; hepatocytes; proteomics; cellular stress; apoptosis; hepatotoxicity; 3D culture; spheroid; drug metabolism; drug toxicity; drug transport; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. READ MORE