Search for dissertations about: "dtm"

Showing result 1 - 5 of 8 swedish dissertations containing the word dtm.

2. 1. Novel Methods for Synthesis of High Quality Oligonucleotides

   Author : Andrey Semenyuk; Marek Kwiatkowski; Ulf Landegren; Joachim W. Engels; Uppsala universitet; []
   Keywords : Organic chemistry; oligonucleotide; solid-phase synthesis; RNA synthesis; phosphoramidite; abasic sites; depurination; 2 -O-DTM; protecting group; cartridge; conjugate; dithiomethyl linker; base-stable linker; oligonucleotide purification; nucleoside; Organisk kemi;

   Abstract : The first part of the work describes a procedure of oligonucleotide purification using a reversed-phase cartridge. The developed method employs a very efficient yet mild oligonucleotide detritylation on the cartridge support allowing fast purification of oligonucleotides regardless of their 5´-modification. READ MORE

4. 2. Keeping track of time : Daily time management, participation, and time-related interventions for children, adolescents, and young adults with neurodevelopmental disorders

   Author : Birgitta Wennberg; Per A Gustafsson; Anette Kjellberg; Gunnel Janeslätt; Maria Larsson-Lund; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ADHD; autonomy; ID; daily time management; intervention; occupational therapy; participation; time assistive devices; time processing ability;

   Abstract : The overall aim of this thesis was to investigate daily time management (DTM) and time-related interventions aiming to enhance participation in everyday activities among school-age children and young adults with neurodevelopmental disorders.In study I, experiences of participation when using time assistive devices (TADs) in daily activities were investigated from the perspective of young adults (aged 17–37) with intellectual disabilities (ID) (n = 9), using semi structured interviews. READ MORE

5. 3. Biomolecular Analysis by Dual-Tag Microarrays and Single Molecule Amplification

   Author : Olle Ericsson; Ulf Landegren; Mats Nilsson; Edwin Southern; Uppsala universitet; []
   Keywords : Molecular medicine; Microarray; proximity ligation; Padlock probe; Rolling circle amplification; Splicing; single molecule; Molekylärmedicin;

   Abstract : Padlock probes and proximity ligation are two powerful molecular tools for detection of nucleic acids and proteins, respectively. Both methods result in the formation of DNA reporter molecules upon recognition of specific target molecules. READ MORE

6. 4. Population Displacement Estimation During Disasters Using Mobile Phone Data

   Author : Silvino Pedro Cumbane; Yifang Ban; Gyözö Gidofalvi; Zeferino Saugene; John Östh; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Geoinformatics; Geoinformatik;

   Abstract : Natural disasters result in devastating losses in human life, environmental assets, and personal-, regional-, and national economies. The availability of different big data such as satellite images, Global Positioning System (GPS)traces, mobile Call Detail Records (CDR), social media posts, etc. READ MORE

7. 5. Proximity Ligation Assays for Disease Biomarkers Analysis

   Author : Rachel Yuan Nong; Ulf Landegren; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; blood biomarkers; protein interactions; pathway analysis; single molecule; next-generation sequencing; Molekylär medicin; Molecular Medicine;

   Abstract : One of the pressing needs in the field of disease biomarker discovery is new technologies that could allow high performance protein analysis in different types of clinical material, such as blood and solid tissues. This thesis includes four approaches that address important limitations of current technologies, thus enabling highly sensitive, specific and parallel protein measurements. READ MORE