Search for dissertations about: "dual physiology"

Showing result 1 - 5 of 24 swedish dissertations containing the words dual physiology.

2. 1. Alpha-2 Adrenergic Receptors and Signal Transduction : Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk

   Author : Johnny Näsman; Peter Evans; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Adrenergic; receptor; G-protein; adenylyl cyclase; cAMP; calcium; cross-talk; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

   Abstract : The alpha-2 adrenergic receptor (α2-AR) subfamily includes three different subtypes, α2A-, α2B- and α2C-AR, all believed to exert their function through heterotrimeric Gi/o-proteins. The present study was undertaken in order to investigate subtype differences in terms of cellular response and to explore other potential signalling pathways of α2-ARs. READ MORE

4. 2. Signaling via Orexin Receptors : A Pharmacological Study

   Author : Tomas Holmqvist; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Per Svenningsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; orexin; receptors; calcium; cAMP; adenylyl cyclases; Fysiologi; Physiology; Fysiologi;

   Abstract : The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation results in, to name but a few effects, elevation of intracellular calcium and depolarisation. READ MORE

5. 3. Aspects on lipoprotein lipase and atherosclerosis

   Author : Lucyna Neuger; Philip Barter; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical physiology; Klinisk fysiologi;

   Abstract : Lipoprotein lipase (LPL) hydrolyses blood lipids at the vascular endothelium. This action makes fatty acids available for tissue metabolic requirements. LPL is anchored to the endothelium by electrostatic forces and may act as a bridge connecting lipoproteins to cell surfaces. READ MORE

6. 4. Autonomic cardiac control in long QT syndrome : clinical studies of arrhythmogenic triggers

   Author : Anna Lundström; Annika Rydberg; Urban Wiklund; Håkan Eliasson; Jacob Tfelt-Hansen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long QT syndrome; pediatrics; exercise; Holter; water immersion; arrhythmia; clinical physiology; ECG; heart rate variability; heart rate response; cardiovascular disease; hjärt- och kärlforskning; kardiologi; Cardiology; pediatrik; Pediatrics;

   Abstract : Background: Long QT syndrome (LQTS) is an inherited cardiac disease characterized by prolonged cardiac repolarization and an increased risk for life-threatening arrhythmias. These arrhythmias are typically triggered by adrenergic stimuli, such as physical activity and intense emotions, implicating that the sympathetic part of the autonomic nervous system (ANS) is involved in arrhythmogenesis. READ MORE

7. 5. Brain Stem Involvement in Immune and Aversive Challenge

   Author : Jakob Paues; Anders Blomqvist; Finn Hallböök; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipopolysaccharide; Lithium Chloride; anorexia; aversion; parabrachial; brain stem; melanocortin; CGRP; enkephalin; Neurobiology; Neurobiologi;

   Abstract : Activation of the immune system by e.g. bacteria induces the acute-phase-response and sickness behaviour. The latter encompasses among other things fever, lethargy, anorexia and hyperalgesia. READ MORE