Search for dissertations about: "duplex melting"

Showing result 1 - 5 of 13 swedish dissertations containing the words duplex melting.

2. 1. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

   Author : Christopher Polonyi; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; duplex melting; thermodynamic stability; kinetics; non-coding RNA; miRNA; siRNA; wobble base pair; loop; BRCA1; mimic; luciferase assay;

   Abstract : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. READ MORE

4. 2. Stainless steels fabricated by laser melting : Scaled-down structural hierarchies and microstructural heterogeneities

   Author : Kamran Saeidi; Zhijian Shen; Xiaoxu Huang; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Selective laser melting; Stainless steel; Structural hierarchies; Microstructure heterogeneity; Mechanical properties; Materials Chemistry; materialkemi;

   Abstract : Additive manufacturing is revolutionizing the way of production and use of materials. The clear tendency for shifting from mass production to individual production of net-shape components has encouraged using selective laser melting (SLM) or electron beam melting (EBM). READ MORE

5. 3. Influence of multiple welding cycles on microstructure and corrosion resistance of a super duplex stainless steel

   Author : Vahid Hosseini; Leif Karlsson; Högskolan Väst; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Super duplex stainless steel; autogenous TIG welding; multiple welding thermal cycles; sensitization; nitrogen loss; sigma phase; ferrite content; production technology; Production Technology; Produktionsteknik; Manufacturing and materials engineering; Produktions- och materialteknik;

   Abstract : Super duplex stainless steel (SDSS) has found a wide use in demanding applications such as offshore, chemical and petrochemical industries thanks to its excellent combination of mechanical properties and corrosion resistance. Welding of SDSS, however, is associated with the risk of precipitation of secondary phases and formation of excessive amounts of ferrite in the weld metal and heat affected zone. READ MORE

6. 4. Cationic Interactions with Nucleic Acids With Focus on Anticancer Active Platinum(II) Complexes

   Author : Åse Sykfont Snygg; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; in-line cleavage; Cisplatin; oxaliplatin; circular dichroism; DENSPM; polyamines; siRNA; pseudoknot; RNA; thermal melting; anticancer active Pt II complex; DNA;

   Abstract : It is well documented that the antitumour activity of the Pt(II)-complex cisplatin, and similar anticancer active complexes, is a result of metalation of DNA, and thereby inhibition of cell proliferation. Since nucleic acids are polyanions at physiological pH, the rate of adduct formation with positively charged complex, as the hydrolyzed Pt(II) complexes studied in this work, is influenced by the ionic environment surrounding the polymer. READ MORE

7. 5. Electron beam powder bed fusion processing of stainless steels

   Author : Stefan Roos; Lars-Erik Rännar; Andrei Koptioug; Carlos Alberto Botero Vega; Iain Todd; Mittuniversitetet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Additive manufacturing; Electron beam powder bed fusion; PBF-EB; Stainless steel; Mechanical properties; Micro-structure; Nanoindentation;

   Abstract : Additive manufacturing (AM) is still a relatively new technology. In contrast to traditional machining where material is removed from a blank, AM is used to fuse a feedstock material into complex shapes, layer by layer, starting from an empty workspace. READ MORE