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Showing result 1 - 5 of 18 swedish dissertations matching the above criteria.

  2. 1. Sorting nexin 9 in clathrin-mediated endocytosis

    Author : Richard Lundmark; Sven Carlsson; Elizabeth Smythe; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; sorting nexin; dynamin; clathrin; endocytosis; human; adaptor protein complexes; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; medicinsk biokemi; Medical Biochemistry;

    Abstract : Clathrin-mediated endocytosis is a process by which cells can internalise diverse molecules such as nutrients, antigens and signalling-surface receptors. The creation of clathrin-coated vesicles demands interplay between the plasma membrane lipids, cargo molecules and the proteins that build up the coat. READ MORE

  4. 2. Analysis of PDGF receptor internalization and signaling using proximity ligation assays

    Author : Marie Rubin Sander; Ola Söderberg; Cristina Al-Khalili Szigyarto; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGFRβ; dynamin; proteolytic cleavage; signaling; internalization; protein-protein interaction; short linear motif; viral hijack; in situ PLA; Molboolean;

    Abstract : Cell signaling is mediated by signaling proteins that relay the signal in an intricate network of interactions before the signal is translated into a biological response. Short linear motifs (SLiMs) in intrinsically disordered regions of proteins serve as docking sites for protein interaction in all aspects of cell regulation including signal transduction. READ MORE

  5. 3. Molecular mechanisms controlling dynamin recruitment to sites of endocytosis by SH3-domain containing proteins

    Author : Anna Sundborger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Endocytosis is a general cellular mechanism, which regulates a number of important events, including recycling of synaptic vesicles. Clathrin-mediated endocytosis is the best-characterized endocytic pathway in the cell. This internalization process involves the coat protein clathrin, the adaptor protein AP2 and a number of accessory proteins. READ MORE

  6. 4. Coordination of endocytosis at the synaptic periactive zone

    Author : Emma Evergren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Synapse; endocytosis; clathrin; dynamin; amphiphysin; synapsin; intersectin; actin cytoskeleton; immunogold electron microscopy.;

    Abstract : Neurons in the central nervous system communicate via specialized junctions called synapses. Neurotransmitter-filled vesicles are clustered at these junctions, where they are released in response to synaptic activity. To sustain reliable neurotransmission the synaptic vesicles are recycled locally. READ MORE

  7. 5. Synaptic vesicle endocytosis studied in a living synapse

    Author : Helge Gad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : synapse; synaptic vesicles; endocytosis; clathrin; calcium; dynamin; endophilin; amphiphysin; synaptojanin; microinjection; electron microscopy;

    Abstract : Neurons in the central nervous system communicate by transmitting electrical signals at special sites of contact called synapses. Synapses contain neurotransmitter-filled synaptic vesicles, which fuse with the presynaptic plasma membrane. The neurotransmitter diffuses to the neighboring neuron and triggers a new electrical signal. READ MORE