Search for dissertations about: "e coli uropathogenic"

Showing result 1 - 5 of 40 swedish dissertations containing the words e coli uropathogenic.

  2. 1. Molecular analysis of transcription factors in uropathogenic E. coli adhesin operons

    Author : Stina Lindberg; Bernt Eric Uhlin; Åsa Sjöling; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; UPEC; E. coli; F1C; P fimbriae; cross-talk; FocB; PapB; crystal structure; OMVs; Medical microbiology; Medicinsk mikrobiologi; molekylärbiologi; Molecular Biology;

    Abstract : The main causative agent of human urinary tract infections is the uropathogenic Escherichia coli (UPEC) pathotype. It may cause disease due to its ability to express a number of bacterial virulence factors. Fimbrial adhesins are particularly important for the initial establishment of infection in the urinary tract. READ MORE

  4. 2. Carbon monoxide and nitric oxide as antimicrobial agents : focus on ESBL-producing uropathogenic E.coli

    Author : Charlotte Sahlberg Bang; Katarina Persson; Bo Söderquist; Annelie Brauner; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biofilm; carbon monoxide; CORM-2; DETA NO; extendedspectrum beta-lactamases; nitric oxide; urinary tract infection; uropathogenic Escherichia coli; Biomedicin; Biomedicine;

    Abstract : Urinary tract infections (UTI) are common in humans and most often caused by uropathogenic Escherichia coli (E. coli). Extended-spectrum beta-lactamase (ESBL)-producing E. coli are increasing worldwide and they are frequently multidrug-resistant with limited treatment options. READ MORE

  5. 3. Pathogenecity-associated genes modulate Escherichia coli adhesion and motility

    Author : Annika E. Sjöström; Bernt Eric Uhlin; Ann-Beth Jonsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Escherichia coli strains typical of UPEC (uropathogenic E. coli) and NBM (newborn meningitis) isolates carry chromosomally located PAIs (pathogenicity islands) that are absent in non-pathogenic E. coli strains. The PAIs include genes for virulence factors such as toxins and genes coding for specific adhesins and pili/fimbriae formation. READ MORE

  6. 4. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions

    Author : Andreas Larsson; Jan Kihlberg; Fredrik Almqvist; Mats Larhed; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Antibacterial; pili; antiadhesive agents; structure based design; statistical molecular design; 2-pyridone; amino acid derivative; galabiose; enaminone; SPR; ELISA; QSAR; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. READ MORE

  7. 5. Synthesis and functionalization of ring-fused 2-pyridones : Targeting pili formation in E. coli

    Author : Nils Pemberton; Fredrik Almqvist; Oliver Kappe; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; acylketene; antibacterial; biofilm inhibitor; Mannich; Micro-wave-assisted chemistry; peptidomimetic; virulence.; Organic synthesis; Organisk syntes;

    Abstract : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. READ MORE