Search for dissertations about: "efavirenz"

Showing result 1 - 5 of 19 swedish dissertations containing the word efavirenz.

  2. 1. Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D

    Author : Maria Ellfolk; Kjell Wikvall; Maria Norlin; Olavi Pelkonen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP2D25; vitamin D 25-hydroxylase; transcriptional regulation; vitamin D; CYP2R1; CYP2J2; CYP27A1; phenobarbital; efavirenz; fibroblast; LNCaP; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Abstract : A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. READ MORE

  4. 2. HIV Persistence and Viral Reservoirs

    Author : Arvid Edén; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; antiretroviral therapy; latency; cerebrospinal fluid; central nervous system; efavirenz; lopinavir; atazanavir; neopterin; viral decay;

    Abstract : Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4+ T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for HIV-1 infection. READ MORE

  5. 3. Quantitative Clinical Pharmacological Studies on Efavirenz and Atazanavir in the Treatment of HIV-1 Infection

    Author : Dinko Rekić; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV; Pharmacokinetics; Pharmacodynamics; Pharmacometrics; AIDS;

    Abstract : There are 34 million people infected with the HIV-1 virus in the world today. Due to increased access to antiretroviral therapy, AIDS related death has dropped by 30% since 2005. READ MORE

  6. 4. Pharmacogenetic aspects of HIV/AIDS, tuberculosis and malaria : emphasis on Ugandan population

    Author : Jackson Kijumba B Mukonzo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Infectious diseases such as HIV, tuberculosis and malaria are endemic in Africa and often require concomitant treatments that may result into subsequent drug–drug interactions. Inter-individual variability in the pharmacokinetics and pharmacodynamics of drugs used in infectious diseases, as a result of genetic polymorphism, has been reported. READ MORE

  7. 5. HIV treatment outcomes in Uganda : the impact of baseline characteristics and variability in pharmacokinetics and pharmacogenetics of antiretroviral drugs

    Author : Sarah Nanzigu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ART Outcomes;

    Abstract : Guidelines specify criteria for initiation and monitoring of antiretroviral treatment (ART), including options for first line regimens. Immunological progress remains a widely used form of HIV/ART monitoring and efavirenz, a preferred first line antiretroviral drug. READ MORE