Search for dissertations about: "effector translocation"

Showing result 1 - 5 of 26 swedish dissertations containing the words effector translocation.

2. 1. Timing and targeting of Type III secretion translocation of virulence effectors in Yersinia

   Author : Sofie Ekestubbe; Åke Forsberg; Roland Rosqvist; Maria Fällman; Kurt Schesser; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system; virulence; translocation; Yersinia pseudotuberculosis; LcrV; YopN; effector targeting; phagocytosis inhibition; YopH; in vivo infection;

   Abstract : The Type III secretion system (T3SS) is an important virulence mechanism that allows pathogenic bacteria to translocate virulence effectors directly into the cytoplasm of eukaryotic host cells to manipulate the host cells in favor of the pathogen. Enteropathogenic Yersinia pseudotuberculosis use a T3SS to translocate effectors, Yops, that prevent phagocytosis by immune cells, and is largely dependent on it to establish and sustain an infection in the lymphoid tissues of a mammalian host. READ MORE

4. 2. Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence

   Author : Margareta Aili; Roland Rosqvist; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; bacterial pathogenesis; YopE; LcrH; virulence; effector translocation; type III secretion; regulation; Cell and molecular biology; Cell- och molekylärbiologi;

   Abstract : In order to establish an extra-cellular infection the gram-negative bacteria Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to translocate a set of anti-host effectors into eukaryotic cells. The toxins disrupt signalling pathways important for phagocytosis, cytokine production and cell survival. READ MORE

5. 3. Delivery of TypeIII Secreted Toxins by Yersinia pseudotuberculosis : the Role of LcrV, YopD, and Free Lipids in the Translocation Process

   Author : Jan Olsson; Hans Wolf-Watz; Ina Attree; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia; T3SS; translocation; YopD; LcrV; YLC; fatty acids.; Molecular biology; Molekylärbiologi;

   Abstract : Bacteria that infect humans and animals face a hard combat with the host´s immune system and in order to establish infection, pathogenic bacteria has evolved mechanisms to avoid being cleared from the host tissue. Many Gram-negatives carry a Type 3 secretion (T3S) system that is used to deliver effector proteins (toxins) into host cells. READ MORE

6. 4. The multifunctional GAP protein YopE of Yersinia is involved in effector translocation control and virulence

   Author : Elin Isaksson; Hans Wolf-Watz; Joseph Barbieri; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia; T3SS; YopE; GAP activity; translocation control; virulence; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : The Gram-negative bacterium Yersinia pseudotuberculosis employs a type 3 secretion system (T3SS) to establish infections. The T3SS translocates a diverse set of effector proteins directly into the host cells. READ MORE

7. 5. Role of the Yersinia protein YopK in microbe-host interactions

   Author : Sara Thorslund; Maria Fällman; James Bliska; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia; YopK; T3SS; antiphagocytosis; neutrophil; translocation; virulence; molekylärbiologi; Molecular Biology;

   Abstract : There are three human pathogenic species of the genus Yersiniae: Yersinia pestis, Yersinia enterocolitica, and Yersinia pseudotuberculosis. To cause disease, these strains inhibit several key innate defense mechanisms, including phagocytosis, the critical process for bacterial clearance. READ MORE