Search for dissertations about: "elastase"

Showing result 1 - 5 of 62 swedish dissertations containing the word elastase.

  2. 1. Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling

    Author : Denise N. Meyer; Kálmán J. Szabó; Dominique Cahard; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; boron; allenylboronic acid; BINOL; homopropargyl alcohol; organocatalyst; organoboron; organofluorine; fluorine; fluorine-18; late-stage; labelling; labeling; nucleophilic; electrophilic; fluorination; positron emision tomography; PET; radiotracer; hypervalent iodine; benziodoxole; benzoxazepines; diaryliodonium salt; metal-free; neutrophil elastase; NE; neutrophil elastase inhibitor; trifluoromethylation; trifluoromethylthiolation; difluoro enol silyl ethers; organisk kemi; Organic Chemistry;

    Abstract : This work is focused on two areas: the chemistry of organofluorine and organoboron compounds. In the first chapter, a copper-catalysed synthesis of tri- and tetrasubstituted allenylboronic acids is presented. Extension of the same method leads to allenylboronic esters. READ MORE

  4. 2. Novel findings on cellular trafficking and targeting for granule storage of neutrophil elastase, a multifunctional effector molecule of innate immunity

    Author : Linda Källquist; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic cell; CD63; neutrophil elastase; targeting; trafficking; intracellular sorting; neutrophil; azurophil granule;

    Abstract : Neutrophil elastase (NE) has important roles in innate immunity, killing pathogens and controlling the immune response; but how NE is targeted to developing granules is not understood. Therefore, the aim of this thesis was to investigate the sorting of NE. READ MORE

  5. 3. Thrombin-induced pulmonary injury in the rat : role of neutrophil elastase and arachidonic acid metabolites

    Author : Chul Min Ahn; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  6. 4. Protein S-100, inflammatory and haemostatic mediators in paediatric open heart surgery. Influence of clinical variables and a biocompatible cardiopulmonary bypass system

    Author : Eva Jensen; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiopulmonary bypass; biocompatible; S-100; Down s syndrome; inflammatory response; complement; cytokines; PMN elastase; haemostasis; coagulation; fibrinolysis;

    Abstract : Cardiopulmonary bypass (CPB) is used in most operations when correcting congenital heart malformations. Postoperative neurological problems (temporary or permanent) are complications of the procedure. These neurological injuries, especially if they are minor, are difficult to recognise in small children. READ MORE

  7. 5. Enzyme Cold Adaptation through Evolution of Protein Flexibility

    Author : Jaka Sočan; Johan Åqvist; Hugo Gutiérrez-de-Terán; Janez Mavri; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EVB; Empirical valence bond method; Pancreatic elastase; α-amylase; Enzyme catalysis; Enzyme evolution; Cold adaptation; Temperature dependence of catalytic rates; Psychrophilic enzyme; Molekylär biovetenskap; Molecular Life Sciences;

    Abstract : What lives, evolves. Macromolecular catalysis is a process, central to both evolutionary and metabolic aspect of life, as it provides a systematic bias favouring certain chemical processes. READ MORE