Search for dissertations about: "elastic net"

Showing result 1 - 5 of 36 swedish dissertations containing the words elastic net.

  1. 1. Comparative network analysis of human cancer: sparse graphical models with modular constraints and sample size correction

    Author : José Sánchez; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Inverse covariance matrix; precision matrix; graphical models; high-dimension; low-sample; networks; sparsity; fused lasso; elastic net; cancer.; fused lasso;

    Abstract : In the study of transcriptional data for different groups (e.g. cancer types) it's reasonable to assume that some dependencies between genes on a transcriptional or genetic variants level are common across groups. Also, that this property is preserved locally, thus defining a modular structure in the model networks. READ MORE

  2. 2. Network models with applications to genomic data: generalization, validation and uncertainty assessment

    Author : José Sánchez; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Inverse covariance matrix; precision matrix; graphical models; high-dimension; low-sample; networks; sparsity; fused lasso; elastic net; cancer; TCGA pan cancer analysis; online resource; discriminant analysis; classification; networks;

    Abstract : The aim of this thesis is to provide a framework for the estimation and analysis of transcription networks in human cancer. The methods we develop are applied to data collected by The Cancer Genome Atlas (TCGA) and supporting simulations are based on derived models in order to reflect real data structure. READ MORE

  3. 3. Mechanisms of adaptation in a mechanoreceptor : a study of mechanical and ionic factors in the crayfish stretch receptors

    Author : Nuhan Purali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Crayfish; stretch receptor; adaptation; visco-elastic properties; mechanosensitive channels; potassium channels; sodium channels; gadolinium; tetraethylammonium chloride; 4-amino pyridine; scorpion venom Leiurus quinquestrialus;

    Abstract : The stretch receptor organ of the crayfish, an analog to the human muscle spindle, is a unique preparation for the study of mechanotransduction. The organ consists of a rapidly and a slowly adapting receptor each composed of a receptor muscle fibre into which inserts the dendrites of a multipolar sensory neuron. READ MORE

  4. 4. Atomic force microscopic studies of inner ear structure and mechanics

    Author : Alexandra Zelenskaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atomic force microscopy; indentation curves; mechanical properties; outer hair cells; shell-core model; electromotility; prestin; otoconia; tympanic membrane.;

    Abstract : The transduction processes occurring in the inner ear, from sound induced vibration or head movements to nerve impulses sent to the brain, are to a large part dependent on the mechanical properties of the different components of this organ, especially the sensory hair cells. The function of the hearing organ is for example dependent on the unique mechanoelectric transduction properties of the cochlear outer hair cells (OHCs), which are able to respond to electrophysiological and mechanical stimulations by changing their shape and their mechanical properties. READ MORE

  5. 5. Vascular function in bicuspid aortic valve disease

    Author : Johan Petrini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aortic valve normally consists of three cusps (tricuspid aortic valve, TAV), but in 0.5-2% of the population it consists of only two cusps (bicuspid aortic valve, BAV), which is the most common congenital cardiac malformation. READ MORE