Search for dissertations about: "electrokinetic chromatography"

Showing result 1 - 5 of 13 swedish dissertations containing the words electrokinetic chromatography.

  2. 1. Studies of Micellar Electrokinetic Chromatography as an Analytical Technique in Pharmaceutical Analysis - an Industrial Perspective

    Author : Karin Stubberud; Brian J. Clark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Micellar Electrokinetic Chromatography; Pharmaceutical Analysis; Chemometrics; Validation; Mass Spectrometry; Partial-filling technique; Pilocarpine; Ibuprofen; Codeine.; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Studies have been performed to evaluate the use of micellar electrokinetic chromatography (MEKC), one mode of capillary electrophoresis (CE), as an analytical technique in industrial pharmaceutical analysis. The potential for using chemometrics for the optimisation of MEKC methods has also been studied as well as the possibilities of coupling MEKC with mass spectrometry (MS). READ MORE

  4. 2. Capillary electroseparations with mass spectrometric detection Nanoparticle-based continuous full filling and applications for complex sample matrices

    Author : Peter Viberg; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytisk kemi; Analytical chemistry; phthalates; continuous full filling; heterocyclic aromatic amines; pseudostationary phase; capillary electrophoresis; electrokinetic chromatography; capillary electrochromatography; nanoelectrospray; mass spectrometry;

    Abstract : One of the major challenges in analytical chemistry is to find techniques and methods for determinations of low abundance compounds in complex sample matrices. This thesis describes the development of new miniaturised analytical techniques comprising capillary electroseparation combined with mass spectrometric detection. READ MORE

  5. 3. Aspects of Optimisation of Separation of Drugs by Chemometrics

    Author : Valérie Harang; Douglas Westerlund; Sven P. Jacobsson; Bo Karlberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; optimisation; separation; chemometrics; high performance liquid chromatography; electrodriven techniques; microemulsion electrokinetic chromatography; statistical experimental design; molecular modelling; chiral separation; cellobiohydrolase; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : Statistical experimental designs have been used for method development and optimisation of separation. Two reversed phase HPLC methods were optimised. READ MORE

  6. 4. Separation of peptides by capillary electrophoresis : Application of chemometrics for evaluation of separation performance in micellar electrokinetic chromatography

    Author : Margrét Thorsteinsdóttir; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : The separation of enkephalin-related peptides and protein kinase A peptide substrates werestudied in micellar electrokinetic chromatography and compared with capillary zoneelectrophoresis. Special interest was focused on systems where the electroosmosis wasreversed in combination with neutral micellar agents. READ MORE

  7. 5. Micellar electrokinetic chromatography with laser-induced fluorescence detection applied to the analysis of biological samples

    Author : Gunnar Thorsén; Andrew G Ewing; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical Chemistry; analytisk kemi;

    Abstract : The research presented in this thesis is focused on the potential for using the combination of micellar electrokinetic chromatography with laser-induced fluorescence detection for the determination of compounds in biological samples. The topics that have been addressed are the development of separation electrolytes, the need for sample preparation procedures, the derivatization of the compounds of interest and the detection of these by laser-induced fluorescence. READ MORE