Search for dissertations about: "electrospray injection"

Showing result 6 - 10 of 10 swedish dissertations containing the words electrospray injection.

2. 6. Liquid chromatography-mass spectrometry in the analysis of radiolabelled compounds for positron emission tomography

   Author : Benita Hyllbrant Forngren; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; Analytical Chemistry; analytisk kemi;

   Abstract : Methods for liquid chromatography-mass spectrometry (LC/MS) with electrospray ionization (ESI) have been developed for the determination of specific radioactivity and for metabolic studies of radiolabelled compounds used in positron emission tomography (PET). These compounds often provide an analytical challenge mainly due to their low concentrations in complex sample matrices. READ MORE

4. 7. High Rate Electron Capture Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

   Author : Youri Tsybin; Per Håkansson; Ron M.A. Heeren; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; mass spectrometry; Fourier transform ion cyclotron resonance; peptides and proteins; ion-electron interaction; electron capture dissociation; infrared multiphoton dissociation; liquid chromatography; capillary electrophoresis; Fysik; Physics; Fysik;

   Abstract : Advances in science and technology during the past decade have greatly enhanced the level of the structural investigation of macromolecules – peptides and proteins. Biological mass spectrometry has become one of the most precise and sensitive techniques in peptide and protein analysis. READ MORE

5. 8. Liquid Chromatography-Mass Spectrometry as a Tool for Drug Metabolite Identification in Biological Fluids : With Application to Ketobemidone

   Author : Ingela Sundström; Per Andrén; Douglas Westerlund; Monika Johansson; Uppsala universitet; []
   Keywords : Analytical chemistry; LC-MS MS; accurate mass measurement; drug metabolites; microdialysate; brain; fluorinated stationary phase; phenylboronic acid; retention mechanism; Analytisk kemi;

   Abstract : Electrospray ionization (ESI) mass spectrometry (MS) in combination with liquid chromatography (LC) is an excellent tool for the identification of drug metabolites. Utilizing this hyphenated technique in combination with proper sample pretreatment, the metabolic pathways of the analgesic drug ketobemidone were investigated in human urine and rat microdialysate from blood and brain. READ MORE

6. 9. Molecular Imaging of Diabetic Kidney Tissue and Binding Studies of Proinsulin C-peptide

   Author : Lina Lindfors; Jan Kihlberg; Ingela Lanekoff; Fredrik Almqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Diabetic kidney disease; Proinsulin C-peptide; GPR146; Mass spectrometry imaging; nano-DESI; Kemi; Chemistry;

   Abstract : Diabetic kidney disease is a serious complication of diabetes with a complex and incompletely understood pathology. In this work, the molecular changes in diabetic rat kidneys at a very early disease stage were studied using nanospray desorption electrospray ionisation mass spectrometry imaging. READ MORE

7. 10. Liquid chromatography : mass spectrometry study of two biochemical alcohol markers

   Author : Niclas Nikolai Stephanson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The interest in biochemical alcohol markers for detecting acute and chronic alcohol consumption has expanded greatly during recent years. The development and application of laboratory tests identifying early problematic drinking and monitoring abstinence have the potential of reducing the healthcare costs and suffering associated with alcohol misuse. READ MORE