Search for dissertations about: "electrospray ionization"

Showing result 1 - 5 of 80 swedish dissertations containing the words electrospray ionization.

  1. 1. Mass Spectrometry with Electrospray Ionization from an Adjustable Gap

    University dissertation from Stockholm : KTH

    Author : Patrik Ek; Åsa Emmer; Johan Roeraade; Per M. Claesson; Ulrika Nilsson; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Electrospray ionization; mass spectrometry; nanoelectrospray; ESI; MS; chip; emitter; gap; liquid bridge; nozzle; peptides; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi;

    Abstract : In this thesis the fabrication and analytical evaluation of two new electrospray emitters utilized for mass spectrometry analysis is presented. The emitters are based on a new concept, where the spray orifice can be varied in size. The thesis is based on two papers.All present-day nanoelectrospray emitters have fixed dimensions. READ MORE

  2. 2. New methods for sensitive analysis with nanoelectrospray ionization mass spectrometry

    University dissertation from Stockholm : KTH

    Author : Patrik Ek; Johan Roeraade; Åsa Emmer; Andries P. Bruins; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; electrospray ionization; nanoelectrospray ionization; adjustable gap; emitter; miniaturization; improved sensitivity; nanoliter picoliter sample volumes; Alzheimer’s disease; amyloid-beta Aβ ; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi;

    Abstract : In this thesis, new methods that address some current limitations in nanoelectrospray mass spectrometry (nESI-MS) analysis are presented. One of the major objectives is the potential gain in sensitivity that can be obtained when employing the proposed techniques. READ MORE

  3. 3. Electrospray Ionization Mass Spectrometry for Determination of Noncovalent Interactions in Drug Discovery

    University dissertation from Stockholm : KTH

    Author : Kurt Benkestock; Johan Roeraade; Renato Zenobi; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; electrospray ionization; drug discovery; noncovalent interaction; complexes; human serum albumin HSA ; fatty acid binding protein FABP ; ribonuclease; ligand screening; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi;

    Abstract : Noncovalent interactions are involved in many biological processes in which biomolecules bind specifically and reversibly to a partner. Often, proteins do not have a biological activity without the presence of a partner, a ligand. READ MORE

  4. 4. Electrophoretic focusing in microchannels combined with mass spectrometry Applications on amyloid beta peptides

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Saara Mikkonen; Åsa Emmer; Johan Jacksén; Tapio Kotiaho; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid beta; computer simulation; electrophoresis; electrospray ionization; isoelectric focusing; isotachophoresis; MALDI; mass spectrometry; microchannel; microchip; nano-electrospray ionization; preconcentration; separation; Kemi; Chemistry;

    Abstract : Analysis of low-abundance components in small samples remains a challenge within bioanalytical chemistry, and new techniques for sample pretreatments followed by sensitive and informative detection are required. In this thesis, procedures for preconcentration and separation of proteins and peptides in open microchannels fabricated on silicon microchips are presented. READ MORE

  5. 5. Applications of nanospray desorption electrospray ionization mass spectrometry In situ lipid and metabolite analysis from cells to tissue

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Martina Marchetti-Deschmann; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; mass spectrometry imaging MSI ; nanospray desorption electrospray ionization nano-DESI ; single-cell analysis; neurotransmitter imaging; diabetic nephropathy; pneumatic nebulization; lipidomics; metabolomics; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : Ambient mass spectrometry (MS) has proved to be an important addition to the bioanalytical toolbox. These methods perform analyte sampling and ionization under atmospheric pressure, and require very little sample preparation other than the sampling process in front of the machine. READ MORE