Search for dissertations about: "embryonic stem cell and toxicity"

Showing result 1 - 5 of 6 swedish dissertations containing the words embryonic stem cell and toxicity.

  2. 1. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    Author : Måns Jergil; Lennart Dencker; Aldert Piersma; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

  4. 2. Oligodendroglial (dys)function in alpha-synucleinopathies

    Author : Carla Azevedo; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synucleinopathies; iPSCs; oligodendrocytes; alpha-synuclein; HLA; cell maturation; immunoproteasome;

    Abstract : The complexity of a-synucleinopathies, which include multiple system atrophy (MSA) and Parkinson’s disease (PD), is not entirely understood. It is known that pathological accumulation of a-synuclein (a-syn) into proteinaceous aggregates is a cellular hallmark of these diseases. READ MORE

  5. 3. Use of genes and cells in regenerative medicine

    Author : Oscar Simonson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Regenerative medicine is a discipline that aims to achieve regeneration of cells, tissue or organs in order to restore or establish normal functions. There are several strategies that can be used to achieve this goal. Many of the strategies are based on use of genes or cells to regenerate organ functions. READ MORE

  6. 4. Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease

    Author : Kioumars Delfani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Parkinson s Disease; apoptosis; substantia nigra; dopamine; MPTP; neurogenesis; intracranial transplantation; ATP; PET; stereology; diethyldithiocarbamate; 7-nitroindazole; mouse; squirrel monkey; non- human primate;

    Abstract : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. READ MORE

  7. 5. Charcterization of biotransformation systems in human cells

    Author : Therese Söderdahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Efforts are continuously being made to improve test procedures so that predictions of toxicity can be made earlier and more accurately. Understanding mechanisms of toxicity is an important part of improving safety assessment, but for this, simplified methods and models to screen for mechanisms associated with toxicity are required. READ MORE