Search for dissertations about: "enantiomer"
Showing result 11 - 15 of 80 swedish dissertations containing the word enantiomer.
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11. Enantioenriched Cyanohydrins and Acetoxyphosphonates – Synthesis and Applications
Abstract : In this thesis, the synthesis of enantioenriched compounds using novel methodologies that employ metal- and biocatalysis is described.In the first part, the synthesis of enantioenriched cyanohydrins, which are highly versatile synthetic intermediates, is described. READ MORE
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12. New Methods for Chiral Cyanohydrin Synthesis
Abstract : This thesis deals with method development in asymmetric catalysis and specifically syntheses of enantioenriched O-functionalized cyanohydrins. The first part describes the development of a method for the synthesis of O‑alkoxycarbonylated and O-acylated cyanohydrins. READ MORE
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13. Forensic Toxicological Aspects of Tramadol : Focus on Enantioselective Drug Disposition and Pharmacogenetics
Abstract : One of the most difficult parts in forensic toxicology is to interpret obtained drug concentrations. Was it therapeutic, toxic or even lethal to the particular individual that the blood sample was drawn from? Concentrations of opioid drugs are especially difficult to interpret, because of large interindividual differences in innate and acquired tolerance. READ MORE
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14. Transition Metal- and Enzyme-Catalyzed Reactions of Primary Amines and Allylic Alcohols : Powerful Tools in the Preparation of Pharmaceutically Important Compounds
Abstract : Dynamic kinetic resolution (DKR) has been applied to primary amines utilizing a ruthenium catalyst and an (R)-selective lipase to provide the corresponding amides in up to 95% isolated yield and up to >99% ee. Further investigations of the chemoenzymatic DKR of amines show that it is general and can be applied to a wide range of amines. READ MORE
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15. Pharmacokinetics of the enantiomers of thalidomide
Abstract : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. READ MORE