Search for dissertations about: "endochondral bone formation"
Showing result 1 - 5 of 9 swedish dissertations containing the words endochondral bone formation.
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1. Molecular regulators in cartilage and bone formation
Abstract : Cartilage functions as a scaffold for bone formation during development. This process, endochondral ossification, is regulated by systemic hormones and local growth factors. READ MORE
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2. Matrix resorption in endochondral bone growth : ultrastructural studies, with special attention to the chondroclast
Abstract : A substantial amount of the calcified cartilage in the distal parts of the epiphyseal plate is resorbed during endochondral growth of long bones. However, the mechanisms involved in this process are still largely unknown. On the other hand, bone-resorption in the lower metaphysis has been thoroughly investigated. READ MORE
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3. Insulin-like growth factor-I from a perspective of bone regeneration
Abstract : The insulin-like growth factor I (IGF-I) is produced by osteoblasts and many other cell types. IGF-I is abundant in bone matrix and mediates some of the effects of growth hormone (GH). The present investigations have focused on IGF-I actions during bone regeneration. READ MORE
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4. Thyroid hormone receptors and the regulation of bone physiology
Abstract : The aim of the studies in this thesis was to investigate the role of thyroid hormone receptors in bone physiology. Thyroid hormone signals through its receptors, the TRs, and has profound effects on bone development and metabolism, as demonstrated in hypo- and hyperthyroidism. READ MORE
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5. Articular and epiphyseal cartilage : its formation, maintenance and repair
Abstract : Long bones develop via a series of ordered processes, initiated from mesenchymal stem cell condensation, cartilage anlagen formation, followed by central cell hypertrophy and vascular invasion and the finalized by the formation of primary and secondary ossification centers (SOC), where the latter is also called endochondral ossification. As long bone develops, it can be distinguished in to several morphologically distinct parts: the main shaft of a long bone, called diaphysis; a narrow disc of growth plate, providing a continuous supply of chondrocytes for longitudinal growth; a thin layer of articular cartilage at the ends of epiphysis, supporting joint movement, and a SOC, sandwiched between the two pieces of cartilage. READ MORE