Search for dissertations about: "endogenous opioid system"

Showing result 16 - 20 of 32 swedish dissertations containing the words endogenous opioid system.

  2. 16. The Impact of Growth Hormone and Gamma-Hydroxybutyrate (GHB) on Systems Related to Cognition

    Author : Jenny Johansson; Mathias Hallberg; Fred Nyberg; Linda Fryklund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth Hormone; Gamma-Hydroxybutyrate; GABAB; Opioids; Insulin-like growth factor 1; Rats; Central Nervous System; Autoradiography; Radioimmunoassay; ELISA; Water Maze; Open Field; Biological Research on Drug Dependence; Biologisk beroendeforskning;

    Abstract : Drug dependence is a serious and increasing problem in our society, especially among adolescents. The use of the large variety of substances available can result in a range of physiological and psychological adverse effects on individuals and negative consequences on the society overall. READ MORE

  4. 17. The Impact of Substance P (SP) N-Terminal Metabolite SP1-7 in Opioid Tolerance and Withdrawal

    Author : Qin Zhou; Tsukasa Sakurada; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The heptapeptide SP1-7, a metabolite of the neuroactive peptide substance P (SP), is suggested to play a role in opioid addiction and memory function. These two dimensions are known to involve dopamine and glutamate transmissions mediated through dopamine receptors and N-methyl-D- aspartate (NNMA) receptors, respectively. READ MORE

  5. 18. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment

    Author : Wei Yu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : allodynia; central pain; ischemia; spinal cord injury; intrathecal; opioid; opioid receptors; selective opioid agonists; selective opioid antagonists; tolerance; dependence; clonidine; bovine chromaffin cells; encapsulation; resiniferatoxin;

    Abstract : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. READ MORE

  6. 19. Treatment of pain behavior after spinal cord injury in rats with special emphasis on the role of adenosine receptors

    Author : Margareta von Heijne; Karolinska Institutet; Karolinska Institutet; []
    Keywords : adenosine; adenosine receptors; allodynia; baclofen; central pain; clonidine; intrathecal; morphine; neuropathic pain; opioid; rat; R-phenylisopropyladenosine; spinal cord injury; tolerance;

    Abstract : Central pain is a form of neuropathic pain occurring after injury or dysfunction in the central nervous system, including the spinal cord. Allodynia (pain to innocuous stimuli) to mechanical and cold stimulation is a common feature of central pain and it is often resistant to treatment. READ MORE

  7. 20. Neurochemical and behavioral studies on ethanol and brain opiod interactions in the brain

    Author : Sara Lindholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Substance dependence is a devastating disorder that produces enormous socio-economic costs, personal tragedies and health related problems. The brain mesolimbic dopamine pathway originating in the ventral tegmental area (VTA) with projections to limbic brain structures such as the nucleus accumbens has been implicated in the reinforcing effects of different drugs of abuse. READ MORE