Search for dissertations about: "endogenous opioid system"

Showing result 21 - 25 of 32 swedish dissertations containing the words endogenous opioid system.

  2. 21. Spectroscopic studies of dynorphin neuropeptides and the amyloid beta-peptide : The consequences of biomembrane interactions

    Author : Loïc Hugonin; Astrid Gräslund; Bernard Lebleu; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biophysics; biofysik;

    Abstract : Dynorphin A, dynorphin B and big dynorphin are endogenous opioid neuropeptides. They play an important role in a wide variety of physiological functions such as regulation of pain processing and memory acquisition. Such actions are generally mediated through the κ-receptors. READ MORE

  4. 22. Maternal Separation in Rats : An Experimental Model for Long-Term Effects of Early Life Experiences on Neurochemistry, Voluntary Ethanol Intake and Exploration and Risk Assessment Behavior

    Author : Erika Roman; Ingrid Nylander; J. Dee Higley; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Handling; Maternal Deprivation; Environment; Opioids; Dopamine; Alcohol; Stress; Concentric Square Field; Open Field; Elevated Plus-maze; Farmaceutisk farmakologi; Pharmaceutical pharmacology; Farmaceutisk farmakologi;

    Abstract : The period of early life is important for the development of individual brain function and behavior. Human studies have shown altered vulnerability to develop psychopathology and/or excessive drug intake, possibly leading to dependence, as a consequence of early life experiences. READ MORE

  5. 23. Mechanisms of Prodynorphin Gene Dysregulation in the Brain of Human Alcoholics

    Author : Malik Mumtaz Taqi; Georgy Bakalkin; Fred Nyberg; Hallberg Mathias; Wolfgang.H Sommer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : The endogenous opioid system (EOS) including dynorphin opioid peptides and κ-opioid receptor (KOR) plays a critical role in alcohol dependence. Aims of the thesis were to evaluate whether the EOS undergoes molecular adaptations in brain areas involved in cognitive control of addiction in human alcohol dependent subjects, and to analyze the impact of genetic and epigenetic factors on these adaptive changes. READ MORE

  6. 24. Estrogen receptor expression in relation to pain modulation and transmission : experimental studies in rats

    Author : Åsa Amandusson; Anders Blomqvist; Kaj Fried; Ola Hermanson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi; MEDICINE;

    Abstract : Estrogens have a remarkably wide range of actions in the mammalian brain. They not only play a pivotal role in reproductive behavior and sexual differentiation, but also contribute to e.g. thermoregulation, feeding, memory, neuronal survival and the perception of somatosensory stimuli. READ MORE

  7. 25. Testing the boundaries for expectation effects in health and disease

    Author : Moa Pontén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Expectations affect our physiology and clinical outcomes, however the boundaries for this modulation are poorly understood. The purpose of this thesis is to investigate minimal requirements to elicit expectation effects on health-related outcomes, using experiments and an independent patient data meta-analysis. READ MORE