Search for dissertations about: "endoglin"

Showing result 1 - 5 of 9 swedish dissertations containing the word endoglin.

  2. 1. THE ROLE OF BMP SIGNALING AND ENDOGLIN IN REGULATION OF HEMATOPOIESIS

    Author : Sofie Singbrant; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-beta superfamily signaling; Conditional knockout mouse; Hematopoietic Stem Cell; Hematopoiesis; Endoglin; BMP;

    Abstract : Hematopoiesis, the formation of blood cells, ultimately depends on a rare population of hematopoietic stem cells (HSCs), which can both self-renew to maintain the HSC pool, and differentiate into all mature blood lineages. HSC fate decisions are governed by a complex combination of numerous signals, although the molecular mechanisms are not fully understood. READ MORE

  4. 2. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice

    Author : Fei Tian; Göteborgs universitet; []
    Keywords : hypoxia; angiogenesis; mice; endoglin; SUMO; PDI;

    Abstract : Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved disappointing. READ MORE

  5. 3. Prognostic markers in prostate cancer : studies of a watchful waiting cohort with long follow up

    Author : Andreas Josefsson; Anders Bergh; Pernilla Wikström; Pär Stattin; Anders Bjartell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Immunohistochemistry; Prognostic markers; biomarkers; Survival analysis; human; pathology; watchful waiting; tissue micro array; Endoglin; von willebrandt factor; ki67; ki-67; hyaluronan; patologi; Pathology;

    Abstract : Background: Prostate Cancer (PC) is a common and highly variable disease. Using current diagnostic methods, the prostate specific antigen (PSA) blood test and histological grading of prostate tissue needle biopsies, it is often difficult to evaluate whether the patient has a PC that requires active treatment or not. READ MORE

  6. 4. Angiogenesis in human renal cell carcinoma : hypoxia, vascularity and prognosis

    Author : Johanna Sandlund; Torgny Rasmuson; Börje Ljungberg; Kjell Grankvist; Anders Bergh; Elisabeth Kjellén; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endoglin CD105; CD31; prognosis; CA IX; HIF-2α; renal cell carcinoma; tissue microarray; immunohistochemistry; real-time PCR; stage; grade; Oncology; Onkologi;

    Abstract : Background: Angiogenesis is recognised as a critical step in tumour progression. The angiogenic switch is activated by various trigger signals, such as hypoxia, low pH, and genetic mutations. Renal cell carcinoma (RCC) is often an aggressive tumour, and advanced disease has limited treatment options and bad prognosis. READ MORE

  7. 5. The role of endoglin in vascular patterning and malformation across diverse vascular beds

    Author : María García Collado; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During development, numerous processes must be finely orchestrated to construct a functional vasculature, essential to sustain life. Hereditary haemorrhagic telangiectasia is a disease characterised by the development of arteriovenous malformations and it is caused in over 80% of the cases by mutations in either endoglin (ENG) or ALK1. READ MORE