Search for dissertations about: "endophilin"

Showing result 1 - 5 of 8 swedish dissertations containing the word endophilin.

  2. 1. Synaptic vesicle endocytosis studied in a living synapse

    Author : Helge Gad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : synapse; synaptic vesicles; endocytosis; clathrin; calcium; dynamin; endophilin; amphiphysin; synaptojanin; microinjection; electron microscopy;

    Abstract : Neurons in the central nervous system communicate by transmitting electrical signals at special sites of contact called synapses. Synapses contain neurotransmitter-filled synaptic vesicles, which fuse with the presynaptic plasma membrane. The neurotransmitter diffuses to the neighboring neuron and triggers a new electrical signal. READ MORE

  4. 2. Molecular mechanisms controlling dynamin recruitment to sites of endocytosis by SH3-domain containing proteins

    Author : Anna Sundborger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Endocytosis is a general cellular mechanism, which regulates a number of important events, including recycling of synaptic vesicles. Clathrin-mediated endocytosis is the best-characterized endocytic pathway in the cell. This internalization process involves the coat protein clathrin, the adaptor protein AP2 and a number of accessory proteins. READ MORE

  5. 3. Studies of membrane-binding proteins involved in synaptic vesicle recycling

    Author : Fredrik Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Signaling between neurons occurs at synapses. A presynaptic nerve terminal releases neurotransmitter, which diffuses over the synaptic cleft, and binds to postsynaptic receptors. Release occurs by fusion of neurotransmitter-containing vesicles with the plasma membrane. READ MORE

  6. 4. Identification of genetic variants and their implications in autoimmunity

    Author : Ulrika Norin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoimmune disorders start to develop when the body’s immune system recognizes organs and tissues as foreign and initiates uncontrolled immune reactions against them. Most of these disorders are regarded as complex with both environmental and genetic factors contributing to disease development. READ MORE

  7. 5. Cbl in Regulation of Growth Factor Receptor Endocytosis and Actin Dynamics

    Author : Iwona Szymkiewicz; Ivan Dikic; Silvia Giordano; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RTK; Cbl; endocytosis; ubiquitination; actin; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Proteins belonging to the Cbl family are multidomain scaffolds that participate in numerous processes, assembling signaling complexes and mediating attachment of ubiquitin to receptor and non-receptor tyrosine kinases.We characterized a novel role for Cbl and Cbl-b in ligand-dependent internalization of growth factor receptors. READ MORE