Search for dissertations about: "endothelium-derived relaxation factor"

Showing result 1 - 5 of 6 swedish dissertations containing the words endothelium-derived relaxation factor.

2. 1. Endothelial function during ischemia-reperfusion and effects of inhalation of nitric oxide

   Author : Lars Lindberg; Anestesiologi och intensivvård; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chemiluminescence; capnography; monitoring; inhalation; mechanical ventilation; pulmonary hypertension; nitric oxide; EDRF; endothelium-derived relaxation factor; endothelium; organ preservation; Lung; lung transplantation; electrochemical fuel cell; Anaesthesiology; intensive care; Anestesiologi; intensivvård;

   Abstract : The vascular endothelium is an important regulatory organ in circulatory physiology and plays a central role in the response to acute inflammation and ischemia/reperfusion. Activation and dysfunction of the pulmonary vascular endothelium are closely related to clinical findings of pulmonary dysfunction. READ MORE

4. 2. Regulation of vascular tone in myometrial resistance arteries in normal pregnancy and preeclampsia

   Author : Karolina Kublickiene; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Atrial natriuretic peptide; Blood vessels; Endothelin-l; Endothelin receptors; Myogenic tone; Myometrial Arteries; Preeclampsia; Pregnancy; Nitric oxide; Shear stress; Vascular endothelium; Vascular smooth muscle .;

   Abstract : Background: Normal pregnancy is characterized by the occurrence of substantial vasodilatation. Pressure responsiveness and vascular reactivity to administered vasoconstrictors undergo considerable attenuation. These circulatory changes are essential to maintain adequate oxygen and nutrient delivery to the placenta and thus to the fetus. READ MORE

5. 3. Vasodilator actions of EDHF and anandamide

   Author : David Andersson; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vanilloid receptors; afferent neurons; anandamide; cannabinoids; potassium channels; hyperpolarization; vasodilation; Vascular endothelium; arteries; airways; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Abstract : Vasodilator responses to endothelium-derived hyperpolarizing factor (EDHF) and anandamide in isolated arteries were investigated. A combination of the potassium channel blockers charybdotoxin and apamin inhibits EDHF-mediated relaxations. READ MORE

6. 4. A study of potassium channel activation as a pharmacological principle for vasodilation of cerebral blood vessels

   Author : Torsten Ryman; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; cerebral arteries; Cerebral ischemia; Potassium channel openers; vascular endothelium; EDHF; KRN2391; KATP; Pinacidil; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Abstract : Increasing [K+]o is intimately coupled to progressive ischemia and reduced CBF. In isolated cerebral and mesenteric arteries, it was found that significant differences in the vascular responses to [K+]o exist. Among the species studied, human cerebral arteries were the most sensitive artery to increasing [K+]o. READ MORE

7. 5. New insights into the control of small artery function in human pregnancy and estrogen receptor beta knockout mice

   Author : Leanid Luksha; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: Available data clearly indicates functional and morphological differences between small and large arteries, and observations from studies on large arteries may not be applicable to understand the physiology of small arteries (~200-300mum) that actively participate in the regulation of peripheral vascular resistance, blood pressure and flow to target organs. These events confer cardiovascular adaptation to normal pregnancy (NP), however they are disturbed in preeclampsia (PE) and in estrogen receptor beta knockout (ERbetaKO) mice at a certain age. READ MORE