Search for dissertations about: "env"
Showing result 1 - 5 of 60 swedish dissertations containing the word env.
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1. Dissection of HIV-1 Env-specific B cell responses in nonhuman primates
Abstract : Vaccine-induced protection is generally mediated by long-lived antigen-specific B cell responses. Most licensed vaccines target pathogens that display relatively low variability, but for highly variable pathogens, such as HIV-1, vaccine development is more challenging. READ MORE
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2. Dissection of HIV-1 Env-specific B cell responses in non-human primates
Abstract : It has been almost 30 years since the identification of HIV as the causative agent of AIDS. Despite considerable efforts to halt the spread of the virus, the epidemic continues in many parts of the world. The most efficient way to stop new infections is a prophylactic vaccine that blocks transmission at the viral portal of entry. READ MORE
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3. Factors influencing the evolution of HIV-1
Abstract : Due to the high replication rate and the low fidelity of the viral reverse transcriptase (RT), various mutations are introduced continuously into the gene pool of HIV-1. Together with recombination events this leads to the evolution of countless quasispecies. READ MORE
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4. Viral dynamics and evolution following primary HIV-1 infection
Abstract : The knowledge of the early events during primary HIV-1 infection (PER) is of great importance for the understanding of the pathogenesis of HIV-1. A major problem in studies on PHI is the limited amount of data accessible from the early time-points. READ MORE
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5. B cell responses against the HIV-1 envelope glycoproteins
Abstract : The fine specificities of vaccine-elicited B cell responses against complex proteins are not well understood, including those directed against the HIV-1 envelope glycoproteins (Env). Env is the only surface-exposed viral protein and hence a major vaccine target, in particular the conserved determinants of Env. READ MORE
