Search for dissertations about: "enzyme function"

Showing result 1 - 5 of 673 swedish dissertations containing the words enzyme function.

  2. 1. The Importance of Being Promiscuous : Understanding enzyme function, specificity, and evolution through structure

    Author : Annika Söderholm; Maria Selmer; Birte Höcker; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Enzyme evolution; enzyme promiscuity; X-ray crystallography.;

    Abstract : Enzymes are known to be amazingly specific and efficient catalysts. However, many enzymes also have so-called promiscuous functions, i.e., they are able to catalyze other reactions than their main one. READ MORE

  4. 2. Towards Classification and Functional Description of Enzymes: A case study of feruloyl esterases

    Author : Gupta Udatha; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; descriptors; enzyme immobilization; catalytic triad; pharmacophore; enzyme promiscuity; functional classification; molecular docking; feruloyl esterases; protein evolution; structure-function relationship;

    Abstract : The prediction of enzyme functionality from sequence or structure data remains a challenging task that can be best addressed by studying the structure-function relationships determined from previously available information. This thesis work was focused on developing a reliable classification and functional description for the feruloyl esterase (FAE) enzyme family, whose members’ possess both structural and catalytic promiscuity. READ MORE

  5. 3. Aldolases for Enzymatic Carboligation : Directed Evolution and Enzyme Structure-Function Relationship Studies

    Author : Huan Ma; Mikael Widersten; Wolf-Dieter Fessner; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aldolase; 2-deoxyribose-5-phosphate aldolase; fructose-6-phosphate aldolase; directed evolution; enzyme dynamics; Biokemi; Biochemistry;

    Abstract : The research summarized in this thesis focuses on directed evolution and enzyme mechanism studies of two aldolases: 2-deoxyribose-5-phosphate aldolase (DERA) and fructose-6-phosphate aldolase (FSA).Aldolases are nature’s own catalysts for one of the most fundamental reactions in organic chemistry: the formation of new carbon-carbon bonds. READ MORE

  6. 4. Plant UDP-glucose Pyrophosphorylase : Function and Regulation

    Author : Meng Meng; Leszek Kleczkowski; Javier Pozueta-Romero; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; UDP-glucose pyrophosphorylase; carbohydrate metabolism; in vivo regulation; T-DNA knockout; heterologous expression; isozyme; mutagenesis; kinetic property; oligomerization; Plant physiology; Växtfysiologi;

    Abstract : UDP-glucose pyrophosphorylase (UGPase) is an important enzyme of carbohydrate metabolism in all living organisms. The main aim of this thesis was to investigate the function and regulation of plant UGP genes as well as the UGPase proteins. READ MORE

  7. 5. Insulin-Degrading Enzyme : A link between insulin resistance and Alzheimer's disease

    Author : Helena Kullenberg; Marie Svedberg; Maria Kumlin; Thomas Nyström; Michael Alvarsson; Sophiahemmet Högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Background: Prior research has demonstrated an elevated risk of Alzheimer's disease (AD) among individuals diagnosed with type 2 diabetes mellitus (T2DM). Insulin resistance is a potential common link between these conditions, and it is associated with AD due to the insulin-degrading enzyme (IDE), which also degrades amyloid-β (Aβ) in the brain. READ MORE