Search for dissertations about: "enzyme kinetic and diseases"

Showing result 1 - 5 of 12 swedish dissertations containing the words enzyme kinetic and diseases.

2. 1. Gene therapy tools: oligonucleotides and peptides

   Author : Jonas Eriksson; Ülo Langel; Jens Kurreck; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene therapy; oligonucleotide; peptide; RNA-cleaving deoxyribozyme; deoxyribozyme; DNAzyme; cell-penetrating peptide; CPP; enzyme; enzyme kinetics; kinetic assay; assay; telomerase; telomerase inhibitor; imetelstat; GRN163L; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. READ MORE

4. 2. Kallikrein-related peptidases in human epidermis : studies on activity, regulation, and function

   Author : Kristina Stefansson; Torbjörn Egelrud; Maria Brattsand; Mona Ståhle; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; desquamation; epidermis; stratum corneum; kallikrein-related peptidase; KLK; serine protease inhibitors; Dermatology and venerology; Dermatologi och venerologi;

   Abstract : Introduction. The outermost layer of the epidermis, the stratum corneum (SC), plays a fundamental role in our defense against microorganisms, chemicals, and dehydration. The SC is composed of tightly packed keratinized skin cells, corneocytes. For a functioning skin it is essential that corneocytes are constantly shed (desquamated). READ MORE

5. 3. PARN – The Tail End : Function and mechanisms of specificity and processivity

   Author : Mikael Nissbeck; Anders Virtanen; Renée Schroeder; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Poly A specific ribonuclease; Adenosine; Specificity; Processivty; Telomere biology disorders; Molekylär cellbiologi; Molecular Cellbiology;

   Abstract : Poly(A)-specific ribonuclease (PARN) is an exoribonuclease that is processive, poly(A) specific and cap-binding. PARN deadenylates the poly(A) tails present on a subset of mRNAs and non-coding RNAs, including among others certain snoRNAs, miRNAs and precursor rRNAs. READ MORE

6. 4. Computational Protein Evolution : Modeling the Selectivity and Promiscuity of Engineered Enzymes

   Author : Klaudia Szeler; Shina C. Lynn Kamerlin; Mikael Widersten; Maria Ramos; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzymes; kinetics; catalysis; density functional theory; empirical valence bond; diesters; evolution; promiscuity; Biokemi; Biochemistry;

   Abstract : Enzymes are biological catalysts that significantly increase the rate of all biochemical reactions that take place within cells and are essential to maintain life. Many questions regarding their function remain unknown. READ MORE

7. 5. Fluorescent Probes and Protein Misfolding: Methods and Applications

   Author : Irem Nasir; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; fluorophores; filter-trap; site-specific fluorophore labeling; amyloid-beta; microscopic rate constants; solvatochromic probes; alpha-synuclein; lipid vesicles; nanoparticles; protein adsorption;

   Abstract : Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. READ MORE