Search for dissertations about: "epigenetic"

Showing result 6 - 10 of 303 swedish dissertations containing the word epigenetic.

  1. 6. HOST EPIGENETIC REGULATOR BMI1 AND VIRAL FIBER PROTEIN FOR EQUILIBRIUM BETWEEN ADENOVIRUS AND HOST

    University dissertation from Neurosurgery, Department of Clinical Sciences, Lund

    Author : Manli Na; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; BMI1; Dual-gene expression; Epigenetic; Equilibrium; Fiber; HSC; HDAC; TSA;

    Abstract : Human adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. READ MORE

  2. 7. Suppressor of zeste 12, a Polycomb group gene in Drosophila melanogaster; one piece in the epigenetic puzzle

    University dissertation from Neurosurgery, Department of Clinical Sciences, Lund

    Author : Anna Birve; Anssi Saura; Allen Shearn; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Drosophila melanogaster; epigenetic; homeotic genes; Polycomb group; PRE; heterochromatin; Suppressor of zeste 12; chromatin silencing; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Genetics; genetik;

    Abstract : In multicellular organisms all cells in one individual have an identical genotype, and yet their bodies consist of many and very different tissues and thus many different cell types. Somehow there must be a difference in how genes are interpreted. So, there must be signals that tell the genes when and where to be active and inactive, respectively. READ MORE

  3. 8. Dementia and its comorbidities : genetic and epigenetic influences

    University dissertation from Stockholm : Karolinska Institutet, Department of Medical Epidemiology and Biostatistics

    Author : Ida K. Karlsson; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Dementia is a multifactorial disorder of late life, characterized by memory deficits, personality changes, and impaired reasoning abilities. There is considerable co-morbidity between dementia, cardiovascular disease (CVD), and late-life depression, but the nature of the associations remains elusive. READ MORE

  4. 9. Epigenetic Regulation by Noncoding RNA

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tanmoy Mondal; Chandrasekhar Kanduri; Jérôme Cavaillé; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genomic Imprinting; Noncoding RNA; Epigenetics; DNA methylation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. READ MORE

  5. 10. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mehdi Motallebipour; Claes Wadelius; Gunnar Westin; Dirk Schübeler; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcription; ChIP-chip; ChIP-seq; genome-wide; transcription factors; microsatellite; epigenetic; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Medical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Medicinsk genetik;

    Abstract : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. READ MORE