Search for dissertations about: "epigenetics"

Showing result 6 - 10 of 111 swedish dissertations containing the word epigenetics.

  2. 6. Epigenetics in nasopharyngeal carcinoma

    Author : Di Sun; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NPC; Methylation; TSG; EBV; LMP1; CDH13; RASSF2A; MMSP;

    Abstract : Nasopharyngeal carcinoma (NPC) shows a remarkably distinctive ethnic and geographic distribution among the world suggesting that genetic susceptibility backgrounds cooperate with the environmental risk factors in etiology of NPCs. Among the environmental factors, much attention has been focused on a well-documented association with Epstein-Barr virus (EBV), which can be detected in 100% undifferentiated NPCs. READ MORE

  4. 7. Epigenetic and Phenotypic Profiling of Urothelial Carcinoma

    Author : Mattias Aine; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetics; DNA methylation; gene expression; urothelial carcinoma; bladder cancer;

    Abstract : Precise spatial and temporal regulation of gene expression programs is a prerequisite for multicellular life. Since the discovery of DNA as the carrier of genetic information, a key question in biology has been how these hard coded instructions are read and regulated to maintain cellular and organismal homeostasis. READ MORE

  5. 8. Growth and Behaviour : Epigenetic and Genetic Factors Involved in Hybrid Dysgenesis

    Author : Wei Shi; Reinald Fundele; Diethard Tautz; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Interspecies hybridization; hybrid dysgenesis effect; speciation; genomic imprinting; epigenetics; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Abstract : In mammals, the most frequently observed hybrid dysgenesis effects are growth disturbances and male sterility. Profound defects in placental development have been described and our work on hybrids in genus Mus has demonstrated putative hybrid dysgenesis effects that lead to defects in lipid homeostasis and maternal behavior. READ MORE

  6. 9. Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content

    Author : Kristina Svennerholm; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardial ischemia; epigenetics; histone deactylase inhibition; t-PA; extracellular vesicles; ischemic preconditioning;

    Abstract : ABSTRACT Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene activity not caused by changes in DNA sequences). READ MORE

  7. 10. Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment

    Author : Daniel Ansari; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; artificial neural networks; apicidin; centralization; early detection; epigenetics; high definition mass spectrometry; MUC4; pancreatic cancer; pancreaticoduodenectomy; prognostic factors; xenograft model; treatment;

    Abstract : Background: Pancreatic cancer is the fourth leading cause of cancer-related death. Only about 6% of patients are alive 5 years after diagnosis. One reason for this low survival rate is that most patients are diagnosed at a late stage, when the tumor has spread to surrounding tissues or distant organs. READ MORE