Search for dissertations about: "epigenome"

Showing result 11 - 15 of 40 swedish dissertations containing the word epigenome.

  2. 11. Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response

    Author : Hani Abdulkadir Ali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of hematopoiesis, including somatic heterozygous mutations, cytogenetic aberrations, or epigenetic aberrations, are found in hematological malignancies. READ MORE

  4. 12. Immune maturation and modulation in childhood allergies : Aspects of epigenetic, mucosal and systemic immune mediators in allergy development and prevention

    Author : Johanna Huoman; Maria Jenmalm; Lennart Nilsson; Petra Ina Pfefferle; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The prevalence of allergic diseases has in the past century increased among children in affluent societies. Underlying causes are incompletely disentangled, but decreased diversity in environmental and microbial exposures could drive allergy development. READ MORE

  5. 13. Functional epigenetic analyses in the context of psychiatric health in adolescence

    Author : Diana-Maria Manu; Helgi B. Schiöth; Elena Raffetti; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Adolescence is a unique and formative period for learning and developing skills and abilities for adulthood. The prevalence of mental health problems in adolescents is estimated to 10-20%, being a major risk for suicide, social and academic impairments. Suicide is the third leading cause of death in older adolescents (15-19 years). READ MORE

  6. 14. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes

    Author : Tasnim Dayeh; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG-SNP; glucagon secretion; insulin secretion; human pancreatic islets; DNA methylation; Epigenetics;

    Abstract : Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. READ MORE

  7. 15. Quantitative methods for profiling dynamic chromatin features

    Author : Banushree Kumar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Living systems, from entire organisms down to the single cells constituting them are dynamic entities that continuously adapt and respond to their local environment. Cells achieve this through gene expression programs derived from static information encoded in the DNA made dynamic through chemical modifications at the chromatin level, collectively termed the epigenome. READ MORE