Search for dissertations about: "epigenome"
Showing result 6 - 10 of 38 swedish dissertations containing the word epigenome.
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6. Exploring the dynamic epigenome in pluripotent stem cells using quantitative methods
Abstract : A totipotent stem cell has the potential to give rise to the trillions of cells in the human body, all carrying the very same genetic information. Through differentiation events, gene expression changes guided by epigenetic mechanisms resulting in specialized phenotypes. READ MORE
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7. The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes
Abstract : Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment in these young children can also be severe. READ MORE
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8. Comparative bioinformatics analyses of transcriptome and epigenome data using bovine model systems
Abstract : Bioinformatics methodology is used to understand complex biological processes in molecular biology, genetics and epigenetics. This thesis performed analysis of the complex biological processes controlling reproduction in mammals including dairy cattle. READ MORE
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9. The search for human skeletal muscle memory : exercise effects on the transcriptome and epigenome
Abstract : Regular physical activity is an environmental stimulus that is highly associated to many health benefits, while physical inactivity is detrimental for health and physical function. Regular exercise training is used in the prevention and treatment of a large number of disease conditions, including obesity, type II diabetes, cardiovascular disease and cancer, and reduces the risk for premature death. READ MORE
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10. Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response
Abstract : The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of hematopoiesis, including somatic heterozygous mutations, cytogenetic aberrations, or epigenetic aberrations, are found in hematological malignancies. READ MORE