Search for dissertations about: "epilepsy 1997"

Showing result 1 - 5 of 9 swedish dissertations containing the words epilepsy 1997.

2. 1. Source localisation of epileptiform activity in epilepsy of temporal lobe origin

   Author : Göran Lantz; Klinisk neurofysiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; frequency analysis; ictal; singe photon emission computed tomography; volume conduction; extracranial; intracranial; LORETA; dipole; source localisation; epilepsy; mesolimbic; Fast Fourier Transform; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : In patients with drug resistant partial epilepsy, who are under consideration for epilepsy surgery, interictal and ictal EEG recorded with extracranial electrodes plays an important role in the localisation of the seizure onset area. During the past years, methods have been developed, which can be used to estimate the location of the source of epileptiform activity in the brain from extracranial EEG data. READ MORE

4. 2. Juvenile myoclonic epilepsy : clinical, genetic, clinical pharmacological, and neurophysiological studies

   Author : Anders Sundqvist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : epilepsy; juvenile myoclonic epilepsy; idiopathic generalised epilepsy; differential diagnosis; genetics; linkage; valproic acid; pharmacokinetics; treatment; drug monitoring; EEG; neurophysiology; neuropsychology. Printed in Sweden by Repro Print; ;

   Abstract : Juvenile myoclonic epilepsy (JME) has been considered to be a discrete phenotype. Evidence from segregation analysis and twin studies suggest that JME is a genetically determined disease, and two previous linkage studies of separately ascertained kindreds have suggested that a JME locus, EJM 1, resides on chromosome 6p close to the HLA region. READ MORE

5. 3. Mechanisms of Hyperexcitability in the Kindling Model of Epilepsy

   Author : Eskil Elmer; Sektion IV; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; Plasticity; Dentate gyrus; Mossy fibers; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Epilepsy is a syndrome characterized by recurring attacks of sudden, excessive and synchronous discharge in populations of cerebral neurons. Kindling is an animal model for complex partial epilepsy, and is particularly useful for studies on the development of the abnormal excitability underlying the generation and spread of epileptic seizures. READ MORE

6. 4. One-year versus three-year treatment of children with uncomplicated epilepsy : a prospective study

   Author : Gunnar Braathen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The main purpose of this prospective study was to investigate whether one-year treatment was equally efficient, regarding the remission rate, as three-year treatment of children with uncomplicated epilepsy. Our aim was also to find any prognostic factors related to the remission rate which would enable us to predict the outcome for the individual child. READ MORE

7. 5. Regulation of NMDA receptor properties by amino acids and cations : a biochemical and electrophysiological study

   Author : Yun Liu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : NMDA receptor; Glutamate; Glycine; [3H]MK-801 binding; Magnesium; Calcium; Tris; Potassium; Sodium; Proton; Xenopus oocytes; Spinal cord; Cerebral cortex; Receptor binding; Electrophysiology;

   Abstract : NMDA receptors are glutamate-regulated ion channels that are permeable to Ca2+, Na+ and K+ and are sensitive to voltage-dependent Mg2+-block. To investigate the modulatory effects of amino acids and cations on NMDA receptors and the possible regional differences in the pharmacology of NMDA receptors, I used mainly two techniques in this thesis: electrophysiological analysis of expressed NMDA receptors in Xenopusoocytes and biochemical receptor binding using [3H]MK-801 in membrane preparations from the rat cerebral cortex and spinal cord. READ MORE