Search for dissertations about: "epileptogenesis"

Showing result 1 - 5 of 11 swedish dissertations containing the word epileptogenesis.

  2. 1. A-type Potassium Channels in Dendritic Integration : Role in Epileptogenesis

    Author : Jenny Tigerholm; Erik Fransén; Fredrik Elinder; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; epileptogenesis; fast ripples; synchronicity; dendritic potentials; transient A–type potassium current; KV 4.2; Computer and systems science; Data- och systemvetenskap;

    Abstract : During cognitive tasks, synchronicity of neural activity varies and is correlated with performance. However, there may be an upper limit to normal synchronised activity – specifically, epileptogenic activity is characterized byexcess spiking at high synchronicity. READ MORE

  4. 2. Development and preclinical assessment of novel therapies for Epilepsy. Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition

    Author : Eliska Waloschkova; Epilepsicentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; epileptogenesis; inhibition; cell therapy; GABAergic interneurons; mesenchymal stem cells; GDNF;

    Abstract : Epilepsy is one of the leading neurological disorders affecting not only patients who suffer from seizures but also people around them and society in general. The striking one third of patients not responding to pharmacological treatments implies the necessity of developing alternative options for controlling seizures in these individuals. READ MORE

  5. 3. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

    Author : Fredrik Berglind; Epilepsicentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Seizure; epileptogenesis; optogenetics; NpHR; ChR2; DREADD; hippocampus; in vivo; mouse;

    Abstract : Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. READ MORE

  6. 4. Mechanisms of Hyperexcitability in the Kindling Model of Epilepsy

    Author : Eskil Elmer; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; Plasticity; Dentate gyrus; Mossy fibers; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Epilepsy is a syndrome characterized by recurring attacks of sudden, excessive and synchronous discharge in populations of cerebral neurons. Kindling is an animal model for complex partial epilepsy, and is particularly useful for studies on the development of the abnormal excitability underlying the generation and spread of epileptic seizures. READ MORE

  7. 5. Mechanisms of excitability in the central and peripheral nervous systems : Implications for epilepsy and chronic pain

    Author : Jenny Tigerholm; Erik Fransén; Dieter Jaeger; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dendritic excitability; synchronized synaptic input; multicompartment model; epilepsy; axonal excitability; silent C–fibres; Hodgkin–Huxley dynamics; conduction velocity; KA;

    Abstract : The work in this thesis concerns mechanisms of excitability of neurons. Specifically, it deals with how neurons respond to input, and how their response is controlled by ion channels and other active components of the neuron. READ MORE