Search for dissertations about: "epistasis effects"

Showing result 1 - 5 of 10 swedish dissertations containing the words epistasis effects.

2. 1. Genomic selection and genome-wide association studies to dissect quantitative traits in forest trees

   Author : Biyue Tan; Pär K. Ingvarsson; Björn Sundberg; Harry X. Wu; Dario Grattapaglia; Xiao-Ru Wang; Leopoldo Sanchez; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Genomic prediction; genome-wide association study; additive effects; dominance effects; epistasis effects; realized relationship matrix; Eucalyptus grandis; Eucalyptus urophylla;

   Abstract : The convergence of quantitative genetics of complex traits with genomic technologies is quickly becoming an innovative approach to explore fundamental genetic questions and also have practical consequences for implementations in tree breeding. In this thesis, I used genomic selection and genome-wide association studies (GWAS) to dissect the genetic basis of quantitative traits, i. READ MORE

4. 2. Complex Trait Genetics : Beyond Additivity

   Author : Simon Forsberg; Örjan Carlborg; Julien Ayroles; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; genetic interactions; epistasis; additivity; GWAS; vGWAS; Genetic mapping; yeast; Arabidopsis Thaliana; dog; Genetik; Genetics;

   Abstract : The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene variants combine their effects in an additive manner. This thesis explores aspects of genetics that cannot be fully captured using such additive models. READ MORE

5. 3. Understanding the genetic basis of complex traits

   Author : Yanjun Zan; Örjan Carlborg; Pär Ingvarsson; Uppsala universitet; []
   Keywords : genetic architecture; complex traits; epistasis; multi-allelic; genotype by environment interaction; polygenic adaptation; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Abstract : Recent advances in genetics and genomics have provided numerous opportunities to study the genetic basis of complex traits. Nevertheless, dissecting the genetic basis of complex traits is still challenged by the complex genetic architecture, in which many genes are involved, and many have small contributions to phenotypic variation, interactions with other genes or environmental factors. READ MORE

6. 4. Mechanisms of Antibiotic Resistance Evolution

   Author : Michael Knopp; Dan Andersson; Anca Segall; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance evolution; Escherichia coli; Salmonella; porins; fitness; epistasis; strain-specificity; sub-MIC; de novo gene evolution;

   Abstract : The continuing emergence and spread of antibiotic resistant bacteria are a threat to various applications in modern medicine and impose a strong economic burden on health systems. The development of new antibiotics is slow and cannot counterbalance the dissemination of resistant bacteria. READ MORE

7. 5. Characterization of Eae4 and Eae19-22 in autoimmune neuroinflammation

   Author : Rita Nohra; Karolinska Institutet; Karolinska Institutet; []
   Keywords : QTL; EAE; MS; epistasis; AIL.;

   Abstract : Multiple Sclerosis (MS) is the most common chronic inflammatory disorders of the central nervous system (CNS) with a prevalence of 1-211000 in the Northern European population. MS is caused by a combination of environmental factors and multiple genes. READ MORE