Search for dissertations about: "epithelial-mesenchymal transition EMT"

Showing result 1 - 5 of 27 swedish dissertations containing the words epithelial-mesenchymal transition EMT.

2. 1. Molecular factors influencing epithelial-mesenchymal transition in breast cancer

   Author : Gisela M A Nilsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; epithelial-mesenchymal transition; c-erbB2; E-cadherin; NFI-C2; FoxF1; LOX;

   Abstract : Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. READ MORE

4. 2. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition

   Author : E-Jean Tan; Aristidis Moustakas; Carl-Henrik Heldin; Geert Berx; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; EMT; HMGA2; Snail; Twist; E-cadherin; epigenetics; invasion; Molekylär cellbiologi; Molecular Cellbiology;

   Abstract : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. READ MORE

5. 3. Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer

   Author : Katja Lundgren; Malmö Patologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta-arrestin1; Chk1; Breast Cancer; Tamoxifen; prognostic marker; predictive marker; gene amplification; cyclin D1; EMT; Snail; hypoxia;

   Abstract : Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. READ MORE

6. 4. Induction of epithelial-mesenchymal transition (EMT) in women's cancer : protective role of differentiation factors

   Author : Joel Johansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Metastatic spread of cancer cells to vital organs is the predominant cause of death among women suffering from breast and ovarian cancer, and invasive cancer cells are in many cases resilient to standard drugs used in the clinic. Consequently, further understanding of the metastatic process and development of new strategies to target invasive cancer cells are needed. READ MORE

7. 5. Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis

   Author : Zehuan Liao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the intricate nature of a 3D tumor microenvironment. READ MORE