Search for dissertations about: "epithelial-mesenchymal transition"

Showing result 1 - 5 of 40 swedish dissertations containing the words epithelial-mesenchymal transition.

  2. 1. Molecular factors influencing epithelial-mesenchymal transition in breast cancer

    Author : Gisela M A Nilsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; epithelial-mesenchymal transition; c-erbB2; E-cadherin; NFI-C2; FoxF1; LOX;

    Abstract : Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. READ MORE

  4. 2. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition

    Author : E-Jean Tan; Aristidis Moustakas; Carl-Henrik Heldin; Geert Berx; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; EMT; HMGA2; Snail; Twist; E-cadherin; epigenetics; invasion; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. READ MORE

  5. 3. Oral lichen planus : studies of factors involved in differentiation, epithelial mesenchymal transition and inflammation

    Author : Karin Danielsson; Karin Nylander; Ylva Britt Wahlin; Linda Boldrup; Jesper Reibel; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oral lichen planus; differentiation; inflammation; autoimmune; premalign; odontologi; Odontology; patologi; Pathology;

    Abstract : Background: Lichen planus is a chronic inflammation of skin and mucosa with unknown cause. Oral Lichen Planus, OLP, affects around 2% of the population. Autoimmunity has been suggested as a possible cause as the disease has autoimmune features such as female predominance, cyclic nature and cytotoxic T-cell infiltrate. READ MORE

  6. 4. Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis

    Author : Zehuan Liao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the intricate nature of a 3D tumor microenvironment. READ MORE

  7. 5. Induction of epithelial-mesenchymal transition (EMT) in women's cancer : protective role of differentiation factors

    Author : Joel Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Metastatic spread of cancer cells to vital organs is the predominant cause of death among women suffering from breast and ovarian cancer, and invasive cancer cells are in many cases resilient to standard drugs used in the clinic. Consequently, further understanding of the metastatic process and development of new strategies to target invasive cancer cells are needed. READ MORE