Search for dissertations about: "epitope mapping"

Showing result 21 - 25 of 32 swedish dissertations containing the words epitope mapping.

  2. 21. Mammalian protein expression and characterization tools for next generation biologics

    Author : Niklas Thalén; Johan Rockberg; Kerstin Otte; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CHO; Cell line engineering; Protein engineering; GFP; Cell display; Biotechnology; Bioteknologi;

    Abstract : Protein therapeutics are increasingly important for modern medicine. Novel recombinant proteins developed today can bind towards their target with high specificity and with low adverse effect. This has enabled the treatment of diseases that for a few years ago were deemed uncurable. READ MORE

  4. 22. Grid and High-Performance Computing for Applied Bioinformatics

    Author : Jorge Andrade; Jacob Odeberg; Luciano Milanesi; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Grid computing; bioinformatics; genomics; proteomics; Bioinformatics; Bioinformatik;

    Abstract : The beginning of the twenty-first century has been characterized by an explosion of biological information. The avalanche of data grows daily and arises as a consequence of advances in the fields of molecular biology and genomics and proteomics. READ MORE

  5. 23. Puumala hantavirus : immune responses and vaccines

    Author : Cristina de Carvalho Nicacio; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hantavirus; Puumala virus; nucleocapsid protein; neutralizing antibodies; Fab fragment; combinatorial library; phage-display; IgA; cellular immunity; cross-protection; intranasal vaccination;

    Abstract : Hantaviruses (family Bunyaviridae) is a group of closely related zoonotic rodent-borne viruses that are transmitted to humans through inhalation of infected rodent excreta. They cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS) with varying degree of severity depending on the causative virus. READ MORE

  6. 24. Genetic studies of non-HLA loci in rheumatoid arthritis : expression and interaction of candidate genes

    Author : Marcus Ronninger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Genetic predisposition is an important contributor in development of human complex diseases, like rheumatoid arthritis (RA). In this thesis work, we present advances for involvement of non-HLA genetic risk factors for RA. READ MORE

  7. 25. Human monoclonal antibody technology. A tool to investigate human antibody repertoires

    Author : Mats Ohlin; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The development of technologies to generate cell lines producing monoclonal antibodies of human origin has a great impact on the ability to study repertoires of specificities in the humoral immune response. Furthermore, it permits the generation of reagents which may be valuable for diagnostic and therapeutic applications and which lack some of the disadvantages of similar murine antibodies. READ MORE