Search for dissertations about: "epitope masking"

Found 5 swedish dissertations containing the words epitope masking.

  1. 1. Antibody Feedback Regulation From Epitope Masking to T Helper Cell Activation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Andrew Getahun; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Immune regulation; B cells; T cells; Antibodies; Fc Receptors; Antigen presentation; Transgenic Knockout Mice; Immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi;

    Abstract : Antibodies have the ability to influence the antibody response against the very antigen they are specific for, in a process called antibody feedback regulation. Depending on the nature of the antigen, the antibody response can be either enhanced or almost completely inhibited. READ MORE

  2. 2. Modulation of B cell access to antigen by passively administered antibodies an explanation for antibody feedback regulation?

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hui Xu; Uppsala universitet.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; IgG3; IgE; suppression; enhancement; epitope masking; antigen transport; antigen presentation; follicular B cells; marginal zone B cells; Immunologi; Immunology;

    Abstract : Antibody responses can be up- or down-regulated by passive administration of specific antibody together with antigen. Depending on the structure of the antigen and the antibody isotype, responses can be completely suppressed or enhanced up to a 1000-fold of what is seen in animals immunized with antigen alone. READ MORE

  3. 3. A Search for the Masked Mechanism Behind IgG-Mediated Suppression of Antibody Responses

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Joakim Bergström; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FcγR; complement; sheep erythrocytes; IgG-mediated immune suppression; rhesus prophylaxis; rhesus D antigen; germinal center; Immunologi; Immunology;

    Abstract : Antibodies passively administered together with their specific antigen can enhance or suppress the specific antibody response. This phenomenon is known as antibody feedback regulation. Whether this modulation causes up- or downregulation of the antibody response depends both on the antibody isotype and the antigen used. READ MORE

  4. 4. Soluble amyloid-β aggregates in Alzheimer’s disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hillevi Englund; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Geriatrics and medical gerontology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Geriatrik och medicinsk gerontologi; Geriatrics; geriatrik;

    Abstract : Soluble oligomeric aggregates of the amyloid-β (Aβ) peptide are suggested to initiate Alzheimer's disease (AD), leading to impaired synapse signalling, widespread neuronal death and loss of cognitive functions. These aggregates seem tightly linked to disease progression, and have therefore gained much attention as potential novel disease markers. READ MORE

  5. 5. Aspects of N-glycosylation in human IgE

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine

    Author : Johanna Da Luz; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The medical interest of allergy in industrialised societies has generated a much greater knowledge about the pathophysiology of IgE-mediated responses than about its normal physiological role. Because of the central role of IgE in allergic inflammation, neutralisation of effector functions and inhibition of IgE-synthesis are attractive means of therapy. READ MORE