Search for dissertations about: "epitope vaccine"

Showing result 1 - 5 of 49 swedish dissertations containing the words epitope vaccine.

  2. 1. Array-based Autoantibody Profiling and Epitope Mapping

    Author : Arash Zandian; Peter Nilsson; Jochen M. Schwenk; Maja Neiman; Morten Nielsen; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody; antigens; peptide; epitope mapping; autoimmunity; autoantibodies; microarrays; Bioteknologi; Biotechnology;

    Abstract : Antibodies are a class of proteins that are made by the immune system to recognize harmful organisms and molecules. Their exceptional capability of specifically recognizing molecules has been investigated for over a century and information thereof has been utilized for a variety of applications including vaccine and generation of therapeutic antibodies. READ MORE

  4. 2. Antibody- and Peptide-based Immunotherapies : Proof-of-concept and safety considerations

    Author : Erika Fletcher; Sara Mangsbo; Vivianne Malmström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune complex; conjugat; vaccine; CD40; whole blood; cytokine release syndrome; Immunologi; Immunology;

    Abstract : The aim of cancer immunotherapy is to eradicate tumours by inducing a tumour-specific immune response. This thesis focuses on how antibodies and peptides can improve antigen presentation and the subsequent tumour-specific T cell response. Tumour recognition by the immune system can be promoted through delivery of antigen in the form of a vaccine. READ MORE

  5. 3. Serology of human papillomavirus type 16

    Author : Xiaohong Wang; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; bacteriology; Microbiology; neutralization; avidity; heparin; epitope; ELISA; HPV16; antibody response;

    Abstract : Human papillomavirus (HPV) type 16 is the major cause of cervical intraepithelial neoplasia and anogenital cancers. The antibody response to papillomaviruses is a key determinant of protective immunity and forms the basis for prophylactic vaccine development as well as for seroepidemiology. READ MORE

  6. 4. Development of a therapeutic vaccine against the hepatitis C virus

    Author : Gustaf Ahlén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; NS3; DNA vaccine; electroporation;

    Abstract : The hepatitis C virus (HCV) infection is a major cause of liver disease and it is estimated that 170 million people worldwide are chronically infected by HCV. There are no protective or curable vaccines available for HCV, however treatment consisting of interferon-α and ribavirin is curative in 45-75% of the chronic infected patients, depending on the viral genotype. READ MORE

  7. 5. Vaccine strategies based on mycobacterial heat shock protein 65

    Author : Maria Sundbäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mycobacteria; DNA vaccination; Hsp65; T cells; CD8 T cell epitopes;

    Abstract : Mycobacteria can infect macrophages and dendritic cells (DC), where they reside inside the endosomal compartment. The importance of CD4+ T cells in protective immunity against mycobacteria and other intracellular pathogens is well established, and for a long time these cells were thought to be the major defense in controlling an infection. READ MORE