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Showing result 1 - 5 of 43 swedish dissertations matching the above criteria.

  2. 1. Cob(I)alamin as a Quantitative Tool for Analysis, Metabolism and Toxicological Studies of Electrophilic Compounds : Butadiene Epoxides, Glycidamide and Sucralose

    Author : Hitesh Vijay Motwani; Margareta Törnqvist; Bernard T Golding; Johanna Haglund; Wolfgang Buckel; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; Miljökemi; Environmental Chemistry; miljökemi;

    Abstract : Vitamin B12 can be reduced to cob(I)alamin [Cbl(I)], which is one of the most powerful nucleophiles known and referred to as a “supernucleophile”. Cbl(I) was applied as a tool in toxicological studies of the air pollutant 1,3-butadiene (BD), the toxicant acrylamide (AA) present in many foods, and the artificial sweetener sucralose. READ MORE

  4. 2. Biochemical Studies on a Plant Epoxide Hydrolase : Discovery of a Proton Entry and Exit Pathway and the Use of In vitro Evolution to Shift Enantioselectivity

    Author : Ann Gurell; Mikael Widersten; Bengt Mannervik; Dick Janssen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; epoxide hydrolase; enantioselectivity; in vitro evolution; proton wire; epoxides; selectivity; CASTing; structure-function; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : The work leading to this thesis has provided additional information and novel knowledge concerning structure-function relationship in the potato epoxide hydrolase. Epoxide hydrolases are enzymes catalyzing the hydrolysis of epoxides to yield the corresponding vicinal diols. READ MORE

  5. 3. Chemo-Enzymatic Epoxidation of Unsaturated Fatty Acids

    Author : Cecilia Orellana Coca Åkerman; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioteknik; Biotechnology; solvent-free process.; Candida antarctica lipase B esterification; chemo-enzymatic epoxidation; Unsaturated fatty acids; epoxides;

    Abstract : Epoxy fatty acids are useful molecules and find a number of applications e.g. as PVC plasticisers and stabilisers, additives in polyurethane production, reactive diluents in paints, corrosion protection agents, etc. READ MORE

  6. 4. Stereoselective Nucleophilic Additions to α-Amino Aldehydes: Application to Natural Product Synthesis

    Author : Per Restorp; Peter Somfai; Timothy J. Donohoe; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Stereoselective synthesis; Substrate-control; α-Amino aldehydes; Mukaiyama aldol; Allylsilanes; [3 2]-Annulation; -Alexine; DGDP; Vinyl epoxides; Regioselectivity; Alkyne nucleophiles; Organic chemistry; Organisk kemi;

    Abstract : This thesis deals with the development and application of new synthetic methodology for stereo- or regioselective construction of carbon-carbon bonds in organic synthesis. The first part of this thesis describes the development of a divergent protocol for stereoselective synthesis of chiral aminodiols by employing Mukaiyama aldol additions to syn- and anti-α-amino-β-silyloxy aldehydes. READ MORE

  7. 5. Quantitative analysis of DNA adducts formed by some epoxides of industrial importance

    Author : Kamila Plná; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA adducts; 32P-postlabelling; cancer; genotoxicity; occupational; epoxides; allyl glycidyl ether; propylene oxide; epichlorohydrin;

    Abstract : The work presented herein has focused on DNA adduct formation by three industrial epoxides, allyl glycidyl ether, propylene oxide and epichlorohydrin. Epoxides, owing to the strained oxirane ring are chemically reactive and can alkylate various sites in DNA. READ MORE