Search for dissertations about: "erbb4"

Showing result 1 - 5 of 7 swedish dissertations containing the word erbb4.

  2. 1. Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family

    Author : Ulrika Andersson; Roger Henriksson; Beatrice Malmer; Erik Blomquist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; glioma; meningioma; endothelium; MDR; Pgp; MRP1; LRP; MGMT; EGFR; ErbB2; ErbB3; ErbB4; Onkologi; Oncology; Onkologi; onkologi; Oncology;

    Abstract : Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. READ MORE

  4. 2. Biological profiles of endocrine breast cancer

    Author : Anna Göthlin Eremo; Sten Wingren; Pia Wegman; Elisabet Tina; Karin Franzén; Agneta Jansson; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrine breast cancer; tamoxifen; Foxl2; Wwox; ErbB4; HER4; gene expression; randomized patients; Biomedicin; Biomedicine;

    Abstract : .... READ MORE

  5. 3. Expression and prognostic value of LRIG1 and the EGF-receptor family in renal cell and prostate cancer

    Author : Marcus Thomasson; Håkan Hedman; Roger Henriksson; Börje Ljungberg; Sten Nilsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Renal cell carcinoma; EGFR; ErbB1-4; LRIG1; Oncology; Onkologi; onkologi; Oncology;

    Abstract : The epidermal growth factor receptor (EGFR) family consists of four (EGFR, ErbB2, Erbb3, and ErbB4) receptor tyrosine kinases (RTK) whose signalling is important for physiological and malignant cellular functions such as proliferation, survival, migration, and differentiation. EGFR and ErbB2 in particular are established oncogenes in many solid tumours and are targets for anti-cancer treatment. READ MORE

  6. 4. GDNF and its receptors : a structure-function analysis of the NCAM-GDNF-GFRalpha1 complex and an examination of potential receptor candidates

    Author : Dan Sjöstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neurotrophic factors are small, secreted proteins that are important players in the development and maintenance of the nervous system. Their functions span from neuronal survival and migration to neurite outgrowth and axon guidance, and in some cases even programmed cell death. READ MORE

  7. 5. Canertinib-induced leukemia cell death signaling : effects of a pan-ERBB inhibitor

    Author : Cecilia Trinks; Thomas Walz; Jan-Ingvar Jönsson; Anna-Lotta Hallbeck; Dan Grandér; Linköpings universitet; []
    Keywords : ;

    Abstract : Acute myelogenous leukemia (AML) is the most common acute leukemia affecting adults, the second most frequent leukemia in children, and remains one of the most difficult to cure. Despite a substantial progress in understanding the pathogenesis of AML, general and rather unspecific cytostatic drugs such as cytarabine and anthracyclins still make up the cornerstones of therapy. READ MORE