Search for dissertations about: "esi-ms"

Showing result 1 - 5 of 83 swedish dissertations containing the word esi-ms.

2. 1. Interfacing HPLC with MALDI- and ESI-MS for Automated High Sensitivity Analysis of Proteins and Peptides

   Author : Tasso Miliotis; Lund Institutionen för kliniska vetenskaper; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; automated; phosphorylation; ZAP-70; peptides; proteins; comprehensive; multidimensional; two-dimensional; piezoelectric; microdispenser; flow-through; ESI-MS MS; Capillary HPLC; MALDI-TOF MS; Analytical chemistry; Analytisk kemi;

   Abstract : The research described in this thesis has an interdisciplinary approach dealing with chemical, biological, and technical issues. One objective was to interface miniaturized liquid chromatography (LC) to mass spectrometry, i.e. MALDI-TOF MS and ESI-MS, in an unattended mode for high sensitivity determination of proteins and peptides. READ MORE

4. 2. Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics

   Author : Leila Zamani; Sven P. Jacobsson; Jonas Bergqvist; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Screening; Fingerprinting; metabolomics; Protein drugs; Mammalian Cell lines; LC ESI-MS; chemometrics; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Abstract : This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. READ MORE

5. 3. Tuning the polylactide hydrolysis rate without introducing new migrants

   Author : Sofia Regnell Andersson; Minna Hakkarainen; Karin Jacobson; Ulrika Edlund; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polylactide; sterocomplex; plasticizer; degradation; degradation products; ESI-MS; Biochemistry; Biokemi; Polymer chemistry; Polymerkemi;

   Abstract : The possibility to control and tune the hydrolytic degradation rate of polylactide without introducing any new degradation products was investigated by subjecting polylactide with cyclic or linear oligolactic acid additives, and a stereocomplex between the L- and D-enantiomers of polylactide to hydrolytic degradation at 37 and 60 °C for up to 39 weeks. The degradation was monitored by measuring mass loss, molar mass changes, water uptake, changes of surface structure, crystallinity and thermal properties. READ MORE

6. 4. Palladium(II)-Catalyzed Coupling Reactions

   Author : Jonas Lindh; Mats Larhed; Matthew S. Sigman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium II ; oxidative Heck reactions; Microwaves; Styrenes; Aryl ketones; Continuous flow; ESI-MS; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Sustainable chemical processes are becoming increasingly important in all fields of synthetic chemistry. Catalysis can play an important role in developing environmentally benign chemical processes, and transition metals have an important role to play in the area of green chemistry. READ MORE

7. 5. Characterisation of the Substituent Distribution in Starch and Cellulose Derivatives

   Author : Sara Richardson; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Analytisk kemi; Cationic amylopectin; Hydroxypropyl amylopectin; Ethyl hydroxyethyl cellulose; Substituent distribution; Enzymic degradation; HPAEC-PAD; MALDI-TOF-MS; ESI-MS; Kemi; Analytical chemistry;

   Abstract : Starch and cellulose can be chemically modified to produce derivatives with specific properties. Knowledge of correlations between the modification reaction, substituent distribution and properties is important in order to design modification processes so as to produce derivatives with the desired properties. READ MORE