Search for dissertations about: "estrogen receptor alpha"

Showing result 16 - 20 of 61 swedish dissertations containing the words estrogen receptor alpha.

  2. 16. Post-translational modification of estrogen receptor alpha and p53 in breast cancer cells

    Author : Jian Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen receptor α (ERα/ESR1) and tumor protein p53 (p53/TP53) signaling are aberrant and play important roles in breast cancer pathogenesis and evolution. ERα is highly expressed in the majority of breast cancers and is an important contributor to the development of these tumors. READ MORE

  4. 17. The relative importance of sex steroid receptors for bone metabolism

    Author : Sofia Movérare-Skrtic; Göteborgs universitet; []
    Keywords : bone; estrogen; androgen; transgenic; microarray;

    Abstract : Estrogen deficiency increases the risk of a wide variety of pathological conditions including osteoporosis. Morbidity from osteoporosis is substantial in both men and women. READ MORE

  5. 18. Function of Innate Immune Cells in Breast Cancer

    Author : Fríða Björk Gunnarsdóttir; Malmö Cancerimmunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor associated macrophages; Breast cancer; Estrogen receptor alpha; FOXO3a; CD169; PD-L1; metastatic lymph node;

    Abstract : Tumor associated macrophages (TAMs) are key cells in creating an immunosuppressive tumor microenvironment (TME). In general, presence of TAMs is associated with worse outcome in cancer patients. Macrophages with anti-tumor effect can be found in the TME but are usually in minority. READ MORE

  6. 19. Molecular mechanisms of estrogen and antiestrogen action

    Author : Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

    Abstract : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. READ MORE

  7. 20. Modulation of estrogen receptors alpha and beta. Effects on the immune system

    Author : Malin Erlandsson; Göteborgs universitet; []
    Keywords : ;

    Abstract : Estrogen affects the development and function of the immune system. Gonadectomized mice treated with estrogen display suppressed T and B lymphopoiesis and inhibited T cell and granulocyte dependent inflammation, while mature B cells are stimulated to produce more immunoglobulins. READ MORE