Search for dissertations about: "evaluation assays"
Showing result 1 - 5 of 111 swedish dissertations containing the words evaluation assays.
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1. Development and evaluation of immunoassays for complement diagnostics
Abstract : Laboratory analyses of human body fluids play an important role in clinical diagnosis. This thesis comprises projects in which various immune assays have been developed and evaluated as complement diagnostics in both plasma and cerebrospinal fluid (CSF). READ MORE
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2. Galectin Inhibitors – Molecular Tools in Biomedical Research and Clinical Implications
Abstract : Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. READ MORE
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3. Towards time-resolved molecular interaction assays in living bacteria
Abstract : Rare and neglected diseases such as multidrug resistant (MDR) tuberculosis, malaria and trypanosomiasis are re-emerging in Europe. New strategies are needed to accelerate drug discovery to fight these pathogens. READ MORE
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4. Biomarkers and mediators in systemic lupus erythematosus : IFNα versus the CRP response, and evaluation of suPAR and anti-dsDNA antibody assays
Abstract : Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease which may affect multiple organ systems. Interferon alpha (IFNα) and autoantibodies that form immune complexes with nuclear antigens (ANA) are hallmarks believed to drive the disease into a vicious circle of inflammation, tissue damage, autoantigen exposure and autoantibody production. READ MORE
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5. Identification and evaluation of growth hormone antagonists
Abstract : States in which Growth hormone (GH) levels are elevated have been implicated in several physiological disorders such as acromegaly, diabetic complications and progression of malignancies. Classical treatments for acromegaly are surgery and radiotherapy but also pharmacological therapies exist. READ MORE