Search for dissertations about: "excitation-contraction"

Showing result 1 - 5 of 8 swedish dissertations containing the word excitation-contraction.

2. 1. Calcium channel activity and force regulation in smooth muscle: Effects of polyamines and growth stimulation

   Author : Maria Gomez; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; verapamil; tissue culture; portal vein; patch-clamp; calcium; spermidine; spermine; polyamines; excitation-contraction; smooth muscle; calcium channel; ionomycin.; Physiology; Fysiologi;

   Abstract : The initial signal for contraction in smooth muscle is an increase in [Ca2+]i. Ca2+ ions can either enter the cytosol from the extracellular medium or be released from intracellular stores. Voltage-operated Ca2+ channels (VOC) play a dominant role in the activation of smooth muscle contraction. READ MORE

4. 2. Modulation of the calcium-force relationship in smooth muscle by polyamines and metabolic inhibition

   Author : Karl Swärd; Cellulär biomekanik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolic inhibition; polyamines; excitation-contraction coupling; smooth muscle; intracellular calcium; Physiology; Fysiologi;

   Abstract : The relationship between intracellular free calcium ([Ca2+]i) and force in smooth muscle was investigated in receptor-coupled permeabilized preparations and by fluorimetry of the calcium indicator Fura 2 in intact smooth muscle. The time integral of spontaneous [Ca2+]i transients in the intact rat portal vein was decreased by cyanide and, during tonic contraction, cyanide reduced force without changing [Ca2+]i implying metabolic sensitivity of both membrane excitation and [Ca2+]i - activation of the contractile proteins. READ MORE

5. 3. A Continuum Framework for Modeling the Excitation–Contraction Coupling of Smooth Muscle

   Author : Babak Sharifimajd; Jonas Stålhand; Anders Klarbring; Markus Böl; Linköpings universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Abstract : Excitation-contraction coupling of smooth muscle refers to a chain of coupled physiological processes which convert a stimulus to a mechanical response. These processes can be disassociated into ionic transport during cell membrane excitation, activation of myosin light chains, and muscle contraction caused by actin-myosin interaction (filament sliding). READ MORE

6. 4. Mechanochemical Modeling of Smooth Muscle Activation

   Author : Sae-Il Murtada; Gerhard A. Holzapfel; Robert McMeeking; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biomechanics; Muscle contraction; Smooth muscle; Contractile unit; Filament overlap; Intracellular calcium; Carotid artery; Mathematical model;

   Abstract : Smooth muscle has an important role in several physiological processes, where it regulates the wall tension and the size of hollow organs. In blood vessels, the contraction and relaxation of smooth muscle contribute to the mechanical stability of the vessel wall and determines the diameter. READ MORE

7. 5. Function of contractile and cytoskeletal proteins in smooth muscle: Effects of hypertrophy and age and desmin removal in a transgenic animal

   Author : Rolf Sjuve; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transgenic mouse; desmin; embryonic myosin; isoforms; myosin heavy chain; age; smooth muscle; hypertrophy; Physiology; Fysiologi;

   Abstract : In man, the urinary bladder responds to an urinary outflow obstruction with a pronounced dilatation and growth of the bladder wall. This clinical situation can be mimicked in rat by creation of a partial urinary outflow obstruction and the papers included in the present thesis use this animal model to address questions regarding the adaptive changes in the smooth muscle of the growing bladder. READ MORE