Search for dissertations about: "exendin- 9-39"

Showing result 1 - 5 of 6 swedish dissertations containing the words exendin- 9-39.

2. 1. Studies of cAMP and Ca2+ signaling in pancreatic islet cells

   Author : Hongyan Shuai; Anders Tengholm; Erik Gylfe; Sebastian Barg; Albert Salehi; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic islet; insulin; glucagon; somatostatin; pancreatic polypeptide; exendin- 9-39 ; GLP-1; GIP; ATP; adenosine; cAMP; Ca2 ; β-cell; α-cell; δ-cell; PP-cell;

   Abstract : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. READ MORE

4. 2. Role of GLP-1 receptor agonists in endothelial function

   Author : Özlem Erdogdu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Type 2 diabetes;

   Abstract : BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis. Hence, there is a need for finding glucose-lowering agents that cause direct positive effects on vasculature in diabetic patients. READ MORE

5. 3. On endothelial function in type 2 diabetic patients with coronary artery disease

   Author : Thomas Nyström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Type 2 diabetes; endothelial dysfunction; insulin resistance; coronary artery disease; nitric oxide; glucagon-like peptide 1; exendin; tetrahydrobiopterin; inflammation; adiponectin; resistin; C-reactive protein; tumor necrosis factor a; interleukin-6;

   Abstract : Patients with type 2 diabetes have a poor outcome suffering a myocardial infarction (MI). Endothelial dysfunction may play a role in this poor prognosis. In type 2 diabetes, endothelial dysfunction is a salient feature coexisting with obesity and insulin resistance and may be linked by the same pathophysiology, i.e. READ MORE

6. 4. Gut peptides in gastrointestinal motility and mucosal permeability

   Author : Md. Abdul Halim; Webb Dominic-Luc; Per M Hellström; Lars Fändriks; Uppsala universitet; []
   Keywords : Gut regulatory peptides; Neuropeptides; Gastrointestinal mucosal permeability; Gastrointestinal motility; GLP-1; NPS; ROSE-010;

   Abstract : Gut regulatory peptides, such as neuropeptides and incretins, play important roles in hunger, satiety and gastrointestinal motility, and possibly mucosal permeability. Many peptides secreted by myenteric nerves that regulate motor control are also produced in mucosal epithelial cells. READ MORE

7. 5. Remote ischemic conditioning to protect the heart in myocardial infarction : therapeutic intervention and underlying mechanisms

   Author : Dinos Verouhis; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: Urgent reperfusion of the occluded coronary artery halts the ischemic insult to the myocardium and is the single most important action to limit infarct size in ST-elevation myocardial infarction. However, reperfusion itself introduces an additional threat to the recovering ischemic myocardium whereby still viable cardiomyocytes suffer additional irreversible damage. READ MORE