Search for dissertations about: "exercise intervention insulin"

Showing result 1 - 5 of 20 swedish dissertations containing the words exercise intervention insulin.

2. 1. Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression

   Author : Siti Maisharah Sheikh Ghadzi; Maria C. Kjellsson; Mats O. Karlsson; Sandra Visser; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometric; type 2 diabetes mellitus; impaired glucose tolerance; prediabetes; anti-diabetes drug development; insulin; glucose; natural diabetes disease progression; lifestyle intervention; short-term provocation; long-term effect; glucose homeostasis; glucose and insulin regulation; weight; dropout; Pharmaceutical Science; Farmaceutisk vetenskap; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

   Abstract : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. READ MORE

4. 2. Effects of a Paleolithic diet and exercise on liver fat, muscle fat and insulin sensitivity

   Author : Julia Otten; Tommy Olsson; Bo Angelin; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; liver fat; Paleolithic diet; exercise training; insulin sensitivity; overweight; intramyocellular lipid content;

   Abstract : Finding ways to reduce risk for obesity-related disorders, including type 2 diabetes and cardiovascular disease, is important. Such approaches can include lifestyle interventions by diet and exercise. Our ancestors in the Paleolithic Era ate a diet based on vegetables, fruit, berries, lean meat, fish, seafood, nuts and eggs. READ MORE

5. 3. Insulin resistance and cardiovascular function - Observational, translational and interventional studies

   Author : Helena Utkovic Westergren; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; microvascular function; peripheral vascular function; coronary flow reserve; prognosis; myocardial perfusion scintigram; animal model;

   Abstract : Background: Microvascular disease is now recognized as an important driver for cardiovascular mortality and morbidity. Diabetic patients are known to suffer from this condition, leading to e.g. coronary ischemia as well as kidney dysfunction. READ MORE

6. 4. Daily living and coping strategies in insulin-dependent diabetics : diagnostic reasoning in nursing

   Author : Berit Lundman; Astrid Norberg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin-dependent diabetes; metabolic control; daily living; coping strategies; attitudes; tedium; smoking habits; menstruation; nursing; diagnostic reasoning in nursing;

   Abstract : Within a defined geographical area, all patients, 192 in total, with insulin- dependent diabetes of at least 2 years' duration and free from long-term diabetic complications were identified. Their experiences of the influence of the disease on daily living, tedium, and smoking habits were evaluated using a questionnaire and related to metabolic control. READ MORE

7. 5. Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation

   Author : Mei Yu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Exercise; skeletal muscle; glucose homeostasis; insulin signal transduction; gene regulation; MAPK cascades; AMPK; MEF2-DNA binding.;

   Abstract : Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression have not been completely elucidated. READ MORE