Search for dissertations about: "exonuclease assay"
Found 4 swedish dissertations containing the words exonuclease assay.
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1. Genetic and environmental risk factors of cervical carcinoma in Situ
Abstract : Invasive cervical cancer is the third most common cancer form among women. In 1990 there were approximately 370,000 new cases diagnosed in the world. The risk of morbidity and mortality of cervical cancer among women is a problem, particularly in the developing countries. READ MORE
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2. Sensitive Forensic DNA Analysis : Application of Pyrosequencing and Real-time PCR Quantification
Abstract : The field of forensic genetics is growing fast and the development and optimisation of more sensitive, faster and more discriminating forensic DNA analysis methods is highly important. In this thesis, an evaluation of the use of novel DNA technologies and the development of specific applications for use in forensic casework investigations are presented. READ MORE
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3. Advancements in Firefly Luciferase-Based Assays and Pyrosequencing Technology
Abstract : Pyrosequencing is a new DNA sequencing method relying on thesequencing-by-synthesis principle and bioluminometric detectionof nucleotide incorporation events. The objective of thisthesis was improvement of the Pyrosequencing method byincreasing the thermal stability of firefly luciferase, and byintroducing an alternative DNA polymerase and a new nucleotideanalog. READ MORE
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4. Quantitative analysis of disease associated mutations and sequence variants
Abstract : A solid-phase sequencing technique was applied to quantify the mitochondrial A3243G mutation in three families with maternally inherited diabetes and deafness. A correlation between the level of heteroplasmy and age at onset was found. READ MORE