Search for dissertations about: "expansion of derivatives"

Showing result 1 - 5 of 24 swedish dissertations containing the words expansion of derivatives.

  2. 1. Serotonergic aporphine derivatives : Synthesis and structure-activity relationships

    Author : Tero Linnanen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Abstract : Novel series of well-characterized and stereochemically pure 11-substituted (R)-aporphine derivatives have been prepared and their interaction with serotonin 5-HT7 and 5-HT1A receptors and dopamine D2A and D1 receptors have been studied. Efficient palladium catalyzed reactions were utilized for the diastereoselective synthesis of atropisomers as well as for the synthesis of several of the other (R)-aporphine derivatives. READ MORE

  4. 2. Development of benzoquinoquinoxaline derivatives as triplex-specific probes : Recognition of DNA structures at repeats sequences

    Author : Helen Bergquist; Rula Zain; Keith Fox; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Triplex; H-DNA; BQQ; BQQ-OP; BQQ-Bodipy; triplet repeat; DNA; non-B-DNA; pkd1; frataxin; Friedreich s ataxia; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Repeat sequences are associated with several human diseases, such as Friedreich’s ataxia, polycystic kidney disease and cancer. These sequences can form non-B-DNA structures, including triplex (H-DNA) DNA, and are associated with genomic instability and altered gene expression. READ MORE

  5. 3. The significance of ethylene and ethylene response factors in wood formation of hybrid aspen

    Author : Bernard Wessels; Hannele Tuominen; Judith Felten; Totte Niittylä; Kurt Fagerstedt; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ethylene; wood formation; hybrid aspen; Populus; ETHYLENE RESPONSE FACTOR; ERF85; ERF139; cambium; lignin; xylem expansion; secondary cell wall; tension wood; cambial derivative cell fate; vessel element; time-lapse photography; molekylär bioteknik inst f nat vet biokemi ; molecular biotechnology dept of biochem ; Genetics; genetik; Physiological Botany; fysiologisk botanik;

    Abstract : The woody tissues serve to stabilise plants, store nutrients and translocate water and minerals. The formation of wood, or ’secondary xylem’, follows a well-defined developmental gradient which is initiated by cell division activity in the vascular cambium. READ MORE

  6. 4. Hit Identification and Hit Expansion in Antituberculosis Drug Discovery : Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors

    Author : Anneli Nordqvist; Anders Karlén; Mats Larhed; Anders Hallberg; Anna Linusson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; Glutamine synthetase; Imidazo[1; 2-a]pyridine analogues; Focused hierarchical design of experiments; DXR; Fosmidomycin analogues; 1-Deoxy-D-xylulose-5-phosphate reductoisomerase; Cinnamaldehydes; Oxidative Heck reaction; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Since the discovery of Mycobacterium tuberculosis (Mtb) as the bacterial agent causing tuberculosis, the permanent eradication of this disease has proven challenging. Although a number of drugs exist for the treatment of tuberculosis, 1.7 million people still die every year from this infection. READ MORE

  7. 5. The Collet-Eckmann condition for rational functions on the Riemann sphere

    Author : Magnus Aspenberg; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Complex dynamics; Riemann sphere; expansion of derivatives;

    Abstract : .... READ MORE