Search for dissertations about: "experimental pharmacological thesis"

Showing result 1 - 5 of 155 swedish dissertations containing the words experimental pharmacological thesis.

  2. 1. Experimental Bladder Reconstruction

    Author : Hans Frederiksen; Urologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; smooth muscle; detrusor; matrix; nerves; subtotal cystectomy; bladder regeneration; enterocystoplasty; nephrology; Urologi; nefrologi;

    Abstract : Reduced urinary bladder capacity is a clinically significant problem. The surgical methods that have been available to treat this, such as urinary diversion or surgically augmenting the bladder by incorporation of intestinal segments, all have serious drawbacks. READ MORE

  4. 2. On intestinal ischaemia after aortoiliac surgery : Epidemiological, clinical and experimental studies

    Author : Martin Björck; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Ischaemia; intestines; colon; ischaemic colitis; aorta-abdominal; aortic aneurysm-abdominal; aortic rupture; atherosclerosis; postoperative complications; cohort studies; case-control studies; clinical protocols; experimental design; incidence; risk factors; diagnosis; treatment outcome; intra-mucosal pH; pHi; swine; splanchnic circulation; haemodynamics; dobutamine; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : An important cause of death among patients undergoing surgery of the abdominal aorta is intestinal ischaemia. In the Swedish Vascular Registry 2930 aortoiliac operations were identified. The complication was studied in a combined cohort and case-control study, and multivariate analysis performed. The incidence of intestinal ischaemia was 2. READ MORE

  5. 3. Leukemia chemotherapy : experimental studies on pharmacological optimisation

    Author : Michèle Masquelier; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our main goal has been to identify new means to improve chemotherapy of acute leukaemia: 1. By using low-density lipoprotein (LDL) as a drug carrier to increase the selectivity of antileukemic drugs, based on high LDL uptake in acute myeloid leukemia (AML) cells. READ MORE

  6. 4. Inner ear proteomics and barriers : Clinical and experimental findings

    Author : Jesper Edvardsson Rasmussen; Göran Laurell; Per Olof Eriksson; Helge Rask-Andersen; Jonas Bergquist; Måns Magnusson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vestibular schwannoma; Hearing loss; Inner ear; Proteome; Perilymph; Endolymph; Furosemide; NKCC1; Fetuin-A; Complement component factor-H realted protein 2; CFHR2; Inflammation; MRI; Oto-Rhino-Laryngology; Oto-rhino-laryngologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Hearing is important in many aspects of life, including communication, assessing one’s surroundings, entertainment and social interaction. Hearing loss is common and according to the Global Burden of Disease Study, 5% of the global population require hearing rehabilitation (1). READ MORE

  7. 5. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

    Author : Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

    Abstract : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. READ MORE