Search for dissertations about: "experimentell patologi"

Showing result 1 - 5 of 25 swedish dissertations containing the words experimentell patologi.

2. 1. Ageing-associated changes of lysosomal compartment : implications on cellular functions

   Author : Yuri Stroikin; Ulf Brunk; Alexei Terman; Karin Öllinger; Suresh Rattan; Linköpings universitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Ageing; Apoptosis; Biological gabarge; Hormesis; Lipofuscin; Lysosome; Pathology; Patologi;

   Abstract : The lysosomal compartment is a major site for intracellular degradation. Lysosomal degradation of the cell’s own constituents, so-called autophagy, not only provides a cell with nutrients, but also removes damaged and potentially dangerous endogenous structures, thus securing intracellular homeostasis. READ MORE

4. 2. Two Types of Fibrils in ATTR Amyloidosis : Implications for Clinical Phenotype and Treatment Outcome

   Author : Elisabet Ihse; Per Westermark; Per Hammarström; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; transthyretin; familial amyloidotic polyneuropathy; TTRV30M; non-TTRV30M; wild-type; liver transplantation; cardiomyopathy; fibril composition; Biokemi; Biochemistry; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Experimentell patologi; Experimental Pathology; Medical Biochemistry; Medicinsk biokemi; Molecular Biology; Molekylärbiologi; Pathology; Patologi;

   Abstract : Systemic amyloidoses are a group of lethal diseases where proteins aggregate into fibrillar structures, called amyloid fibrils, that deposits throughout the body. Transthyretin (TTR) causes one type of amyloidosis, in which the aggregates mainly infiltrate nervous and cardiac tissue. READ MORE

5. 3. Alzheimer's Disease Neuropathological Change and neuronal and glial alterations in patients with idiopathic Normal Pressure Hydrocephalus

   Author : Sylwia Libard; Irina Alafuzoff; Anna Dimberg; Per Kristian Eide; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; idiopathic Normal Pressure Hydrocephalus; Alzheimer’s disease; amyloid β; hyperphosphorylated τ; Patologi; Pathology;

   Abstract : Alzheimer’s disease Neuropathological Change (ADNC), i.e. amyloid β (Aβ) and hyperphosphorylated τ (HPτ), is seen in excess in the brains of subjects with AD. READ MORE

6. 4. Lysosomal Membrane Stability and Cathepsins in Cell Death

   Author : Hanna Appelqvist; Karin Öllinger; Katarina Kågedal; Petra Wäster; Maria Shoshan; Linköpings universitet; []
   Keywords : ;

   Abstract : Lysosomes are acidic organelles that are critically involved in a number of physiological processes, including macromolecule degradation, endocytosis, autophagy, exocytosis and cholesterol homeostasis. Several pathological conditions, such as cancer, neurodegenerative disorders and lysosomal storage diseases, involve lysosomal disturbances, indicating the importance of the organelle for correct cellular function. READ MORE

7. 5. Lysosomal Membrane Permeabilization : A Cellular Suicide Strategy

   Author : Ann-Charlotte Johansson; Karin Öllinger; Karin Roberg; Boris Zhivotovsky; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; lysosomes; lysosomal membrane permeabilization; cathepsins; Bax; Bid; mitochondria; caspases; Cell and molecular biology; Cell- och molekylärbiologi;

   Abstract : In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis signaling and execution has been achieved.The aim of this thesis was to clarify the role of lysosomal membrane permeabilization and lysosomal proteases, cathepsins, in signaling for apoptosis. READ MORE